Asymmetric Dynamics of the Native Aortic Annulus Evaluated by Force Transducer and Sonomicrometry in a Porcine Model.

Autor: Benhassen LL; Department of Clinical Medicine, Aarhus University Hospital, Skejby, Aarhus, Denmark. benhassen@clin.au.dk.; Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark. benhassen@clin.au.dk., Ropcke DM; Department of Clinical Medicine, Aarhus University Hospital, Skejby, Aarhus, Denmark.; Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark., Lading T; Department of Clinical Medicine, Aarhus University Hospital, Skejby, Aarhus, Denmark.; Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark., Skov JK; Department of Clinical Medicine, Aarhus University Hospital, Skejby, Aarhus, Denmark.; Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark., Bechsgaard T; Department of Clinical Medicine, Aarhus University Hospital, Skejby, Aarhus, Denmark.; Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark.; Department of Engineering, Faculty of Science and Technology, Aarhus University, Aarhus, Denmark., Skov SN; Department of Clinical Medicine, Aarhus University Hospital, Skejby, Aarhus, Denmark.; Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark., Nielsen SL; Department of Clinical Medicine, Aarhus University Hospital, Skejby, Aarhus, Denmark.; Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark., Hasenkam JM; Department of Clinical Medicine, Aarhus University Hospital, Skejby, Aarhus, Denmark.; Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark.
Jazyk: angličtina
Zdroj: Cardiovascular engineering and technology [Cardiovasc Eng Technol] 2019 Sep; Vol. 10 (3), pp. 482-489. Date of Electronic Publication: 2019 Jun 07.
DOI: 10.1007/s13239-019-00418-1
Abstrakt: Purpose: With new repair techniques of the aortic root and valve emerging, a detailed understanding of the dynamics of the aortic annulus and valve is required for optimal results. The objective of this study was to characterize geometrical changes and force distribution of the native porcine aortic annulus throughout the cardiac cycle.
Methods: Measurements were performed in an acute 80 kg porcine model (n = 7) using sonomicrometry crystals in the aortic annulus for evaluation of geometry and dynamics, annular force transducer evaluating force distribution, and pressure measurements and echocardiography evaluating valve performance.
Results: Overall, segmental force distribution and geometrical changes differed between different segments of the aortic annulus. The highest force development was found at the left/right interleaflet triangle (2.87 ± 2.1 N) and the largest segmental expansion was observed at the right-coronary and left-coronary sinus. The aortic annulus changed configuration throughout the cardiac cycle and became more oval in systole.
Conclusions: This study is the first to describe detailed segmental dynamics and force distribution of the native aortic annulus in a porcine model in vivo. The heterogenous behavior of the aortic annulus suggests that different segments demand different support for repair of the aortic root and valve.
Databáze: MEDLINE
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