Update on adrenal steroid hormone biosynthesis and clinical implications.

Autor:	Bacila IA; Academic Unit of Child Health, Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK., Elder C; Academic Unit of Child Health, Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK., Krone N; Academic Unit of Child Health, Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
Jazyk:	angličtina
Zdroj:	Archives of disease in childhood [Arch Dis Child] 2019 Dec; Vol. 104 (12), pp. 1223-1228. Date of Electronic Publication: 2019 Jun 07.
DOI:	10.1136/archdischild-2017-313873
Abstrakt:	Steroid biosynthesis is a complex process in which cholesterol is converted to steroid hormones with the involvement of multiple enzymes and cofactors. Inborn conditions affecting adrenal steroidogenesis are relatively common in paediatric practice and have serious implications on patient mortality and morbidity. This paper provides an overview of novel insights into human adrenal steroid biosynthesis. Inborn errors of steroidogenesis associated with congenital adrenal hyperplasia are discussed, with a particular focus on the pathophysiology and clinical features of 21-hydroxylase deficiency. The final section of the review presents more recent findings and clinical implications of adrenal-specific androgen biosynthesis. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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