Effects of drug abuse, smoking and alcohol on donor hearts and lungs.

Autor: MacGowan GA; Department of Cardiology, Freeman Hospital, Newcastle upon Tyne, UK.; Department of Cardiothoracic Transplantation, Freeman Hospital, Newcastle upon Tyne, UK.; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK., Dark JH; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK., Corris PA; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK., Nair AR; Department of Cardiothoracic Transplantation, Freeman Hospital, Newcastle upon Tyne, UK.; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.; Department of Respiratory Medicine, Freeman Hospital, Newcastle upon Tyne, UK.
Jazyk: angličtina
Zdroj: Transplant international : official journal of the European Society for Organ Transplantation [Transpl Int] 2019 Oct; Vol. 32 (10), pp. 1019-1027. Date of Electronic Publication: 2019 Jun 28.
DOI: 10.1111/tri.13468
Abstrakt: Potential heart and lung donors with a history of illicit drugs and/or smoking and alcohol are frequently offered, though there is no clear guidance on when it is safe to use these organs. A review of the literature on effects of drugs, alcohol and smoking on donor outcomes, and the effects of these on the intact heart and lung was undertaken. There has been a marked increase in deaths from opioid abuse in many developed countries, though recent evidence suggests that outcomes after cardiothoracic transplantation are equivalent to nonopioid donor causes of death. For donor smoking, there is an increased risk with lung transplantation; however, that risk is less when compared to further waiting on the transplant list for a nonsmoking alternative. Heavy alcohol consumption does not adversely affect heart transplantation, and there is no clear evidence of adverse outcomes after lung transplantation. There are no overall effects of cannabis or cocaine on survival after heart or lung transplantation. In all these cases, careful donor assessment can establish if a particular organ can be used. In most cases, use of drugs requires careful assessment, but is not in of itself a contraindication to cardiothoracic transplantation.
(© 2019 Steunstichting ESOT.)
Databáze: MEDLINE
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