Impact of autoimmune rheumatic diseases on birth outcomes: a population-based study.

Autor:	Strouse J; Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA., Donovan BM; Internal Medicine, Vanderbilty University Medical Center, Iowa City, Iowa, USA., Fatima M; Internal Medicine, Iowa City VA Medical Center, Iowa City, Iowa, USA., Fernandez-Ruiz R; Internal Medicine, NYU Langone Health, New York, New York, USA., Baer RJ; Pediatrics, University of California San Diego Health System, San Diego, California, USA., Nidey N; Epidemiology, University of Iowa, Iowa City, Iowa, USA., Forbess C; Internal Medicine, Harbor-UCLA Medical Center, Torrance, California, USA., Bandoli G; Pediatrics, University of California San Diego Health System, San Diego, California, USA., Paynter R; Epidemiology and Biostatistics, University of California San Francisco School of Medicine, San Francisco, California, USA., Parikh N; Internal Medicine, Div of Cardiology, University of California San Francisco School of Medicine, San Francisco, California, USA., Jeliffe-Pawlowski L; Epidemiology and Biostatistics, University of California San Francisco School of Medicine, San Francisco, California, USA., Ryckman KK; Epidemiology, University of Iowa, Iowa City, Iowa, USA., Singh N; Rheumatology, Iowa City VA Medical Center, Iowa City, Iowa, USA.; Rheumatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
Jazyk:	angličtina
Zdroj:	RMD open [RMD Open] 2019 Apr 14; Vol. 5 (1), pp. e000878. Date of Electronic Publication: 2019 Apr 14 (Print Publication: 2019).
DOI:	10.1136/rmdopen-2018-000878
Abstrakt:	Objectives: Autoimmune rheumatic diseases (ARDs) affect women of childbearing age and have been associated with adverse birth outcomes. The impact of diseases like ankylosing spondylitis and psoriatic arthritis (PsA) on birth outcomes remains less studied to date. Our objective was to evaluate the impact of ARDs on preterm birth (PTB), congenital anomalies, low birth weight (LBW) and small for gestational age (SGA), in a large cohort of women. Methods: We conducted a propensity score-matched analysis to predict ARD from a retrospective birth cohort of all live, singleton births in California occurring between 2007 and 2012. Data were derived from birth certificate records linked to hospital discharge International Classification of Diseases, ninth revision codes. Results: We matched 10 244 women with a recorded ARD diagnosis (rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), antiphospholipid syndrome, PsA); ankylosing spondylitis and juvenile idiopathic arthritis (JIA) to those without an ARD diagnosis. The adjusted OR (aOR) of PTB was increased for women with any ARD (aOR 1.93, 95% CI 1.78 to 2.10) and remained significant for those with RA, SLE, PsA and JIA. The odds of LBW and SGA were also significantly increased among women with an ARD diagnosis. ARDs were not associated with increased odds of congenital anomalies. Conclusion: Consistent with prior literature, we found that women with ARDs are more likely to have PTB or deliver an SGA infant. Some reassurance is provided that an increase in congenital anomalies was not found even in this large cohort. Competing Interests: Competing interests: None declared.
Databáze:	MEDLINE
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