Neurons and glial cells in bipolar disorder: A systematic review of postmortem brain studies of cell number and size.

Autor: Gigase FAJ; Department of Psychiatry, Brain Center, University Medical Center Utrecht, Utrecht University (BCRM-UMCU-UU), 3584 CG Utrecht, the Netherlands., Snijders GJLJ; Department of Psychiatry, Brain Center, University Medical Center Utrecht, Utrecht University (BCRM-UMCU-UU), 3584 CG Utrecht, the Netherlands., Boks MP; Department of Psychiatry, Brain Center, University Medical Center Utrecht, Utrecht University (BCRM-UMCU-UU), 3584 CG Utrecht, the Netherlands., de Witte LD; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, NY, USA; Mental Illness Research, Education and Clinical Center (MIRECC), James J Peters VA Medical Center, Bronx, NY, USA. Electronic address: Lotje-dewitte@mssm.edu.
Jazyk: angličtina
Zdroj: Neuroscience and biobehavioral reviews [Neurosci Biobehav Rev] 2019 Aug; Vol. 103, pp. 150-162. Date of Electronic Publication: 2019 Jun 01.
DOI: 10.1016/j.neubiorev.2019.05.027
Abstrakt: Bipolar disorder (BD) is a complex neurobiological disease. It is likely that both neurons and glial cells are affected in BD, yet how these cell types are changed at the structural and functional level is still largely unknown. In this review we provide an overview of postmortem studies analyzing structural cellular changes in BD, including the density, number and size of neurons and glia. We categorize the results per cell-type and validate outcome measures per brain region. Despite variations by brain region, outcome measure and methodology, several patterns could be identified. Total neuron, total glia, and cell subtypes astrocyte, microglia and oligodendrocyte presence appears unchanged in the BD brain. Interneuron density may be decreased across various cortical areas, yet findings of interneuron subpopulations show discrepancies. This structural review brings to light issues in validation and replication. Future research should therefore prioritize the validation of existing studies in order to increasingly refine the conceptual models of BD.
(Copyright © 2019 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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