β-adrenergic modulation of discrimination learning and memory in the auditory cortex.

Autor: Schicknick H; Special Lab Molecular Biological Techniques, Leibniz Institute for Neurobiology, Magdeburg, Germany., Henschke JU; Department Systems Physiology of Learning, Leibniz Institute for Neurobiology, Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research, Otto von Guericke University Magdeburg, Magdeburg, Germany., Budinger E; Department Systems Physiology of Learning, Leibniz Institute for Neurobiology, Magdeburg, Germany.; Center for Behavioral Brain Sciences, Magdeburg, Germany., Ohl FW; Department Systems Physiology of Learning, Leibniz Institute for Neurobiology, Magdeburg, Germany.; Center for Behavioral Brain Sciences, Magdeburg, Germany.; Institute of Biology, Otto von Guericke University Magdeburg, Magdeburg, Germany., Gundelfinger ED; Center for Behavioral Brain Sciences, Magdeburg, Germany.; Department Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, Magdeburg, Germany.; Molecular Neurobiology, Medical Faculty, Otto von Guericke University Magdeburg, Magdeburg, Germany., Tischmeyer W; Special Lab Molecular Biological Techniques, Leibniz Institute for Neurobiology, Magdeburg, Germany.; Center for Behavioral Brain Sciences, Magdeburg, Germany.
Jazyk: angličtina
Zdroj: The European journal of neuroscience [Eur J Neurosci] 2019 Oct; Vol. 50 (7), pp. 3141-3163. Date of Electronic Publication: 2019 Jul 01.
DOI: 10.1111/ejn.14480
Abstrakt: Despite vast literature on catecholaminergic neuromodulation of auditory cortex functioning in general, knowledge about its role for long-term memory formation is scarce. Our previous pharmacological studies on cortex-dependent frequency-modulated tone-sweep discrimination learning of Mongolian gerbils showed that auditory-cortical D 1/5 -dopamine receptor activity facilitates memory consolidation and anterograde memory formation. Considering overlapping functions of D 1/5 -dopamine receptors and β-adrenoceptors, we hypothesised a role of β-adrenergic signalling in the auditory cortex for sweep discrimination learning and memory. Supporting this hypothesis, the β 1/2 -adrenoceptor antagonist propranolol bilaterally applied to the gerbil auditory cortex after task acquisition prevented the discrimination increment that was normally monitored 1 day later. The increment in the total number of hurdle crossings performed in response to the sweeps per se was normal. Propranolol infusion after the seventh training session suppressed the previously established sweep discrimination. The suppressive effect required antagonist injection in a narrow post-session time window. When applied to the auditory cortex 1 day before initial conditioning, β 1 -adrenoceptor-antagonising and β 1 -adrenoceptor-stimulating agents retarded and facilitated, respectively, sweep discrimination learning, whereas β 2 -selective drugs were ineffective. In contrast, single-sweep detection learning was normal after propranolol infusion. By immunohistochemistry, β 1 - and β 2 -adrenoceptors were identified on the neuropil and somata of pyramidal and non-pyramidal neurons of the gerbil auditory cortex. The present findings suggest that β-adrenergic signalling in the auditory cortex has task-related importance for discrimination learning of complex sounds: as previously shown for D 1/5 -dopamine receptor signalling, β-adrenoceptor activity supports long-term memory consolidation and reconsolidation; additionally, tonic input through β 1 -adrenoceptors may control mechanisms permissive for memory acquisition.
(© 2019 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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