Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity.

Autor: Kazak L; Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada. lawrence.kazak@mcgill.ca.; Department of Biochemistry, McGill University, Montreal, Quebec, Canada. lawrence.kazak@mcgill.ca., Rahbani JF; Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.; Department of Biochemistry, McGill University, Montreal, Quebec, Canada., Samborska B; Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.; Department of Biochemistry, McGill University, Montreal, Quebec, Canada., Lu GZ; Dana-Farber Cancer Institute, Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Jedrychowski MP; Dana-Farber Cancer Institute, Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Lajoie M; Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.; Department of Biochemistry, McGill University, Montreal, Quebec, Canada., Zhang S; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Ramsay L; Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.; Department of Biochemistry, McGill University, Montreal, Quebec, Canada., Dou FY; Dana-Farber Cancer Institute, Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Tenen D; Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Chouchani ET; Dana-Farber Cancer Institute, Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Dzeja P; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Watson IR; Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.; Department of Biochemistry, McGill University, Montreal, Quebec, Canada., Tsai L; Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Rosen ED; Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Spiegelman BM; Dana-Farber Cancer Institute, Department of Cell Biology, Harvard Medical School, Boston, MA, USA. bruce_spiegelman@dfci.harvard.edu.
Jazyk: angličtina
Zdroj: Nature metabolism [Nat Metab] 2019; Vol. 1 (3), pp. 360-370. Date of Electronic Publication: 2019 Feb 25.
DOI: 10.1038/s42255-019-0035-x
Abstrakt: Competing Interests: Competing interests. The authors declare no competing interests
Databáze: MEDLINE