Platelet-derived growth factor-beta as a new marker of deep venous thrombosis.

Autor: Alhabibi AM; Department of Clinical Pathology, Faculty of Medicine (For Girls), Al-Azhar University, Cairo, Egypt., Eldewi DM; Department of Clinical Pathology, Faculty of Medicine (For Girls), Al-Azhar University, Cairo, Egypt., Wahab MAA; Department of Vascular Surgery, Faculty of Medicine (For Girls), Al-Azhar University, Cairo, Egypt., Farouk N; Department of Vascular Surgery, Faculty of Medicine (For Girls), Al-Azhar University, Cairo, Egypt., El-Hagrasy HA; Department of Clinical Pathology, Faculty of Medicine (For Girls), Al-Azhar University, Cairo, Egypt., Saleh OI; Department of Radio-Diagnosis, Faculty of Medicine (For Girls), Al-Azhar University, Cairo, Egypt.
Jazyk: angličtina
Zdroj: Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences [J Res Med Sci] 2019 May 22; Vol. 24, pp. 48. Date of Electronic Publication: 2019 May 22 (Print Publication: 2019).
DOI: 10.4103/jrms.JRMS_965_18
Abstrakt: Background: Deep venous thrombosis (DVT) is associated with significant morbidity and mortality. Thus, there is a great need to demonstrate a more efficient biomarker that would confirm the diagnosis of DVT. Our work aimed to evaluate the role of platelet-derived growth factor-beta (PDGF-B) as a new marker of DVT and its correlation with other radiological and laboratory tools used for the diagnosis.
Materials and Methods: A case-control study enrolled forty patients selected from our university hospital between April 2018 and August 2018, who divided into two groups: Group I ( n = 20) consisted of patients diagnosed with acute venous thrombosis and Group II ( n = 20) consisted of patients diagnosed with chronic venous thrombosis. Twenty samples were collected from age- and gender-matched apparently healthy controls to be used as a control. Venous duplex ultrasonography, routine laboratory investigations, D-dimer (DD), and protein expression of PDGF-B were performed on all patients.
Results: There was a highly significant increase in a protein expression of PDFG-B in all cases of acute and chronic venous thrombosis compared to the control group with P < 0.001; furthermore, it was more specific than DD for the detection of DVT (specificity 95% and 90%, respectively).
Conclusion: Our study submits a novel association of PDGF-B plasma levels with DVT, and PDGF-B is considered to be a more specific indicator for DVT than is DD.
Competing Interests: There are no conflicts of interest.
Databáze: MEDLINE
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