Stability and compatibility of ondansetron with haloperidol in parenteral admixtures.

Autor:	Estan-Cerezo G; Servicio de Farmacia, Hospital General Universitario de Elche-FISABIO, Elche, Spain., Matoses-Chirivella C; Servicio de Farmacia, Hospital General Universitario de Elche-FISABIO, Elche, Spain., Soriano-Irigaray L; Servicio de Farmacia, Hospital General Universitario de Elche-FISABIO, Elche, Spain., Murcia-López AC; Servicio de Farmacia, Hospital General Universitario de Elche-FISABIO, Elche, Spain., Rodríguez-Lucena FJ; Servicio de Farmacia, Hospital General Universitario de Elche-FISABIO, Elche, Spain., Navarro-Ruiz A; Servicio de Farmacia, Hospital General Universitario de Elche-FISABIO, Elche, Spain.
Jazyk:	angličtina
Zdroj:	European journal of hospital pharmacy : science and practice [Eur J Hosp Pharm] 2018 Jul; Vol. 25 (4), pp. 200-203. Date of Electronic Publication: 2017 Apr 13.
DOI:	10.1136/ejhpharm-2016-001200
Abstrakt:	Background: The chemical stability of coadministered ondansetron (OND) and haloperidol (HAL) in parenteral admixtures has not been described yet. Objective: The aim of the present work is to study the chemical stability and the compatibility of OND and HAL admixtures. Methods: Normal saline solution and dextrose were used to prepare the admixture solutions of the drugs; the materials of the containers were the original plastic bags of the diluents and the stability was studied at 20°C. Compatibility was studied by visual inspection of no colour change and turbidity or precipitation appearance. The concentration of the drugs was studied by ultraviolet detection high-performance liquid chromatography. The method was validated following the Food and Drug Administration and European Medicines Agency guidelines, and the assay enables the measurement of both drugs with a linear calibration curve (r=0.999) over the concentration range 10-100 µg/mL, with acceptable values of linearity, precision and accuracy. Darunavir was used as internal standard. Results: Most of the admixtures have an adequate concentration until 24 hours(less than 10% of loss). 25% of the samples show a higher loss at 24 hours, and the chemical stability of these samples is 12 hours. Conclusions: The stability and compatibility of OND and HAL in the coadministered admixtures in Viaflo plastic bags with normal saline or dextrose are suggested at 12 hours. Competing Interests: Competing interests: None declared.
Databáze:	MEDLINE
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