Generalizability of a Diabetes-Associated Country-Specific Exploratory Dietary Pattern Is Feasible Across European Populations.

Autor:	Jannasch F; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; NutriAct-Competence Cluster Nutrition Research Berlin-Potsdam, Nuthetal, Germany., Kröger J; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg, Germany., Agnoli C; Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Barricarte A; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Navarra Public Health Institute, Pamplona, Spain.; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain., Boeing H; Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany., Cayssials V; Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain., Colorado-Yohar S; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Department of Epidemiology, Murcia Health Council, IMIB-Arrixaca, Spain.; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia., Dahm CC; Section for Epidemiology, Department of Public Health, Aarhus University, Denmark., Dow C; Inserm, Centre for Research in Epidemiology and Population Health [CESP], Villejuif, France; Université Paris-Sud, Villejuif, France., Fagherazzi G; Inserm, Centre for Research in Epidemiology and Population Health [CESP], Villejuif, France; Université Paris-Sud, Villejuif, France., Franks PW; Department of Clinical Sciences, Lund University, Malmö, Sweden.; Department of Public Health and Clinical Medicine, Umeå University, Sweden., Freisling H; Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France., Gunter MJ; Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France., Kerrison ND; MRC Epidemiology Unit, University of Cambridge, United Kingdom., Key TJ; Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom., Khaw KT; Department of Public Health and Primary Care, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom., Kühn T; German Cancer Research Center [DKFZ], Heidelberg, Germany., Kyro C; Danish Cancer Society Research Center, Copenhagen, Denmark., Mancini FR; Inserm, Centre for Research in Epidemiology and Population Health [CESP], Villejuif, France; Université Paris-Sud, Villejuif, France., Mokoroa O; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Public Health Division of Gipuzkoa, Biodonostia Research Institute, San Sebastian, Spain., Nilsson P; Department of Clinical Sciences, Lund University, Malmö, Sweden., Overvad K; Section for Epidemiology, Department of Public Health, Aarhus University, Denmark.; Department of Cardiology, Center for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark., Palli D; Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network-ISPRO, Florence, Italy., Panico S; Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy., García JRQ; Public Health Directorate, Asturias, Spain., Rolandsson O; Department of Public Health and Clinical Medicine, Umeå University, Sweden., Sacerdote C; Unit of Cancer Epidemiology, Citta'della Salute e della Scienza Hospital-University of Turin and Center for Cancer Prevention (CPO), Torino, Italy.; Human Genetics Foundation (HuGeF), Torino, Italy., Sánchez MJ; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Andalusian School of Public Health, Granada, Spain., Sahrai MS; Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France., Schübel R; German Cancer Research Center [DKFZ], Heidelberg, Germany., Sluijs I; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands., Spijkerman AMW; National Institute for Public Health and the Environment [RIVM], Bilthoven, Netherlands., Tjonneland A; Danish Cancer Society Research Center, Copenhagen, Denmark., Tong TYN; Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom., Tumino R; Cancer Registry and Histopathology Unit, 'Civile - M.P. Arezzo' Hospital, Ragusa, Italy.; Associazone Iblea per la Ricerca Epidemiologica-Onlus, Ragusa, Italy., Riboli E; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, United Kingdom., Langenberg C; MRC Epidemiology Unit, University of Cambridge, United Kingdom., Sharp SJ; MRC Epidemiology Unit, University of Cambridge, United Kingdom., Forouhi NG; MRC Epidemiology Unit, University of Cambridge, United Kingdom., Schulze MB; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Institute of Nutritional Sciences, University of Potsdam, Nuthetal, Germany., Wareham NJ; MRC Epidemiology Unit, University of Cambridge, United Kingdom.
Jazyk:	angličtina
Zdroj:	The Journal of nutrition [J Nutr] 2019 Jun 01; Vol. 149 (6), pp. 1047-1055.
DOI:	10.1093/jn/nxz031
Abstrakt:	Background: Population-specificity of exploratory dietary patterns limits their generalizability in investigations with type 2 diabetes incidence. Objective: The aim of this study was to derive country-specific exploratory dietary patterns, investigate their association with type 2 diabetes incidence, and replicate diabetes-associated dietary patterns in other countries. Methods: Dietary intake data were used, assessed by country-specific questionnaires at baseline of 11,183 incident diabetes cases and 14,694 subcohort members (mean age 52.9 y) from 8 countries, nested within the European Prospective Investigation into Cancer and Nutrition study (mean follow-up time 6.9 y). Exploratory dietary patterns were derived by principal component analysis. HRs for incident type 2 diabetes were calculated by Prentice-weighted Cox proportional hazard regression models. Diabetes-associated dietary patterns were simplified or replicated to be applicable in other countries. A meta-analysis across all countries evaluated the generalizability of the diabetes-association. Results: Two dietary patterns per country/UK-center, of which overall 3 dietary patterns were diabetes-associated, were identified. A risk-lowering French dietary pattern was not confirmed across other countries: pooled HRFrance per 1 SD: 1.00; 95% CI: 0.90, 1.10. Risk-increasing dietary patterns, derived in Spain and UK-Norfolk, were confirmed, but only the latter statistically significantly: HRSpain: 1.09; 95% CI: 0.97, 1.22 and HRUK-Norfolk: 1.12; 95% CI: 1.04, 1.20. Respectively, this dietary pattern was characterized by relatively high intakes of potatoes, processed meat, vegetable oils, sugar, cake and cookies, and tea. Conclusions: Only few country/center-specific dietary patterns (3 of 18) were statistically significantly associated with diabetes incidence in this multicountry European study population. One pattern, whose association with diabetes was confirmed across other countries, showed overlaps in the food groups potatoes and processed meat with identified diabetes-associated dietary patterns from other studies. The study demonstrates that replication of associations of exploratory patterns with health outcomes is feasible and a necessary step to overcome population-specificity in associations from such analyses. (Copyright © American Society for Nutrition 2019.)
Databáze:	MEDLINE
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