THE ROMANIAN VERSION OF THE THYROID-RELATED PATIENT-REPORTED OUTCOMES THYPRO AND THYPRO-39. TRANSLATION AND ASSESSMENT OF RELIABILITY AND CROSS-CULTURAL VALIDITY.

Autor: Zahan AE; University of Medicine and Pharmacy of Tîrgu Mures, Dept. of Histology, Tirgu Mures, Romania.; University of Medicine and Pharmacy of Tîrgu Mures, Emergency County Hospital, Tîrgu Mures, Dept. of Endocrinology, Tirgu Mures, Romania., Watt T; Copenhagen University Hospital Rigshospitalet, Dept. of Medical Endocrinology, Odense, Denmark., Pascanu I; University of Medicine and Pharmacy of Tîrgu Mures, Dept. of Endocrinology, Tirgu Mures, Romania.; University of Medicine and Pharmacy of Tîrgu Mures, Emergency County Hospital, Tîrgu Mures, Dept. of Endocrinology, Tirgu Mures, Romania., Rasmussen AK; Copenhagen University Hospital Rigshospitalet, Dept. of Medical Endocrinology, Odense, Denmark., Hegedüs L; Odense Universitetshospital, Odense, Denmark., Bonnema SJ; Odense Universitetshospital, Odense, Denmark., Feldt-Rasmussen U; Copenhagen University Hospital Rigshospitalet, Dept. of Medical Endocrinology, Odense, Denmark., Bjorner JB; Institute of Public Health, University of Copenhagen, Copenhagen,Denmark., Nadasan V; University of Medicine and Pharmacy of Tîrgu Mures, Dept. of Hygiene, Tirgu Mures, Romania., Boila A; University of Medicine and Pharmacy of Tîrgu Mures, Dept. of Histology, Tirgu Mures, Romania., Merlan I; University of Medicine and Pharmacy of Tîrgu Mures, Emergency County Hospital, Tîrgu Mures, Dept. of Endocrinology, Tirgu Mures, Romania., Borda A; University of Medicine and Pharmacy of Tîrgu Mures, Dept. of Histology, Tirgu Mures, Romania.
Jazyk: angličtina
Zdroj: Acta endocrinologica (Bucharest, Romania : 2005) [Acta Endocrinol (Buchar)] 2018 Apr-Jun; Vol. 14 (2), pp. 192-200.
DOI: 10.4183/aeb.2018.192
Abstrakt: Background: ThyPRO is a recently developed thyroid-specific quality of life (QoL) questionnaire applicable to patients with benign thyroid disorders(BTD). The aim of the present study was to translate ThyPRO and ThyPRO-39 into Romanian, and to evaluate reliability and cross-cultural validity.
Methods: Standard methodology for translation and linguistic validation of patient-reported outcomes (PRO) was applied. The questionnaire was completed by 130 patients with benign thyroid diseases seen at Department of Endocrinology in the Emergency County Hospital, Tîrgu Mureş, Romania, between October 2015 and March 2016. Internal reliability of the Romanian version of the ThyPRO (ThyPROro) scales was assessed for multi-item scales using Cronbach's alpha coefficient. An efficient method for testing cross-cultural validity is analysis of differential item functioning (DIF). Uniform DIF between the Romanian and the original Danish sample was investigated using ordinal logistic regression. The translation process proceeded without difficulties, and any disagreements were revised by one of the developers and the language coordinator.
Results: Internal reliability for ThyPRO was satisfactory. Cronbach`s alpha coefficients for the 13 scales ranged from 0.78 to 0.93 for the ThyPROro and 0.78 to 0.87 for the ThyPROro-39. In the 85-item ThyPRO, nine instances of DIF were found. Most were minor, explaining <3% of the variation in scale score, but DIF in positively worded items were larger, with explained variance (R2's) around 10-15%.
Conclusion: The ThyPROro questionnaire is ready for assessment of health-related quality of life in Romanian patients with benign thyroid diseases.
Competing Interests: The authors declare that they have no conflicts of interest. Researchers interested in using the Romanian ThyPROro or the ThyPRO-39ro may contact the corresponding author. For other language versions, contact Torquil Watt.
Databáze: MEDLINE
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