| Autor: |
Samedy LA; Department of Pharmacy Practice, Mercer University, College of Pharmacy, 3001 Mercer University Drive, Atlanta, GA 30341, USA., Ryan GJ; Department of Pharmacy Practice, Mercer University, College of Pharmacy, 3001 Mercer University Drive, Atlanta, GA 30341, USA., Superko RH; PRIMA Heart Clinic, 1010 Cass St, Monterey, CA 93940, USA., Momary KM; Department of Pharmacy Practice, Mercer University, College of Pharmacy, 3001 Mercer University Drive, Atlanta, GA 30341, USA. |
| Abstrakt: |
Aim: To assess the association between the CETP Taq1B and I405V polymorphisms with levels of lipoprotein subclasses in African-American (AA) men with and without Type 2 diabetes (T2DM). Patients & methods: AA men, over 30 years of age, with (n = 54) or without T2DM (n = 50), and not receiving lipid-lowering agents, underwent advanced lipid analysis and genotyping. Results & conclusion: In the total patient population Taq1B B2-allele carriers had significantly higher levels of large HDL subclasses (HDL-2b [p = 0.017] and HDL-L [p = 0.019]), lower levels of small-HDL subclasses (HDL-3a [p = 0.004] and HDL-3b [p = 0.031]), and lower levels of LDL subclasses (LDL-IVa [p = 0.012] and LDL-IIIb [p = 0.009]). The only significant genotype-diabetes interaction occurred with the HDL-2a subclass (p = 0.015). No statistically significant associations were seen with I405V genotype. Our observations of lower levels of small-HDL and higher levels of large-HDL suggest that a potentially important HDL subclass- CETP relationship exists. |
