What is the best biological parameter to predict erectile dysfunction in men aged >55 years with type 2 diabetes?

Autor: Raharinavalona SA; Department of Endocrinology and Diabetology, University Hospital of Guadeloupe, Les Abymes, Guadeloupe, France., Chevalier N; Department of Endocrinology, Diabetology, Reproduction, Hôpital de l'Archet, Centre Hospitalier Universitaire de Nice, Université Côte d'Azur, Inserm UMR U1065/UNS, Nice, France., Gruel C; Department of Endocrinology and Diabetology, University Hospital of Guadeloupe, Les Abymes, Guadeloupe, France., N'toutoum AC; Department of Endocrinology and Diabetology, University Hospital of Guadeloupe, Les Abymes, Guadeloupe, France., Vélayoudom Céphise FL; Department of Endocrinology and Diabetology, University Hospital of Guadeloupe, Les Abymes, Guadeloupe, France.; L.A.M.I.A EA-4540, University of Antilles, Guadeloupe, France.
Jazyk: angličtina
Zdroj: Journal of diabetes investigation [J Diabetes Investig] 2020 Jan; Vol. 11 (1), pp. 170-173. Date of Electronic Publication: 2019 Jul 08.
DOI: 10.1111/jdi.13089
Abstrakt: To date, there is no evidence regarding the best biological marker to predict erectile dysfunction (ED) in men aged >55 years with type 2 diabetes. This prospective study included data from men aged >55 years with type 2 diabetes. ED was assessed by the International Index of Erectile Function 15-item survey. Total testosterone (TT) levels and bioavailable testosterone were measured; the free testosterone index was calculated. Data from 155 men (aged 64 ± 7 years) were explored. The prevalence of ED and testosterone deficiency was 78.7% and 34.8%, respectively. After univariate analysis, TT and bioavailable testosterone were associated with ED (P = 0.01). After multivariate analysis, and adjustment for age, body mass index, tobacco, alcohol, duration of diabetes, TT, bioavailable testosterone, vitamin D and high-sensitivity C-reactive protein, we found that only high-sensitivity C-reactive protein was significantly predictive of ED. TT could predict ED, but it lacks specificity. We found a potential role of high-sensitivity C-reactive protein as a predictive marker of ED in this targeted population.
(© 2019 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje