Histoplasmosis, heart failure, hemolysis and haemophagocytic lymphohistiocytosis.
| Autor: | Gupta N; Department of Medicine, All India Institute of Medical Sciences, New Delhi, India., Vinod KS; Department of Medicine, All India Institute of Medical Sciences, New Delhi, India., Mittal A; Department of Medicine, All India Institute of Medical Sciences, New Delhi, India., Kumar APA; Department of Medicine, All India Institute of Medical Sciences, New Delhi, India., Kumar A; Department of Medicine, All India Institute of Medical Sciences, New Delhi, India., Wig N; Department of Medicine, All India Institute of Medical Sciences, New Delhi, India. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | The Pan African medical journal [Pan Afr Med J] 2019 Jan 23; Vol. 32, pp. 43. Date of Electronic Publication: 2019 Jan 23 (Print Publication: 2019). |
| DOI: | 10.11604/pamj.2019.32.43.14954 |
| Abstrakt: | Histoplasmosis is an endemic mycosis with global distribution, primarily reported in immunocompromised individuals. A 29-year old immunocompetent male presented with fever, hepatosplenomegaly and pancytopenia. His peripheral blood showed features suggestive of intravascular hemolysis and echocardiography showed features suggestive of pulmonary arterial hypertension. Bone marrow showed yeast with morphology suggestive of Histoplasma capsulatum . Further investigations revealed hyperferritinemia, hypofibrinogenemia and increased triglycerides. With a diagnosis of progressive disseminated histoplasmosis with secondary Haemophagocytic lymphohistiocytosis, he was successfully treated with amphotericin B followed by itraconazole. We report this case to highlight the atypical and rare manifestations of histoplasmosis. Competing Interests: The authors declare no competing interests. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|