The correlation between possible RBD and cognitive function in Parkinson's disease patients in China.

Autor: Yan YY; Department of Neurology China-Japan Union Hospital Jilin University Changchun 130033 China., Lei K; Department of Neurology Weinan Center Hospital Weinan 714000 China., Li YY; Department of Neurology China-Japan Union Hospital Jilin University Changchun 130033 China., Liu XF; Department of Neurology China-Japan Union Hospital Jilin University Changchun 130033 China., Chang Y; Department of Neurology China-Japan Union Hospital Jilin University Changchun 130033 China.
Jazyk: angličtina
Zdroj: Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2019 Apr 13; Vol. 6 (5), pp. 848-853. Date of Electronic Publication: 2019 Apr 13 (Print Publication: 2019).
DOI: 10.1002/acn3.747
Abstrakt: Objective: Cognitive impairment is an important symptom of Parkinson's disease (PD) and seriously affects patients' quality of life and prognosis. However, its cause is still uncertain. In about one-third of patients, PD is associated with rapid eye movement sleep behavior disorder (RBD), which is an independent risk factor for PD-associated dementia; but whether or not it relates to the cognitive function of patients with nondemented PD is still controversial.
Methods: The data from 89 enrolled PD patients were retrospectively analyzed. The RBD Questionnaire Hong-Kong (RBD-HK) was used to diagnose possible RBD (pRBD). There are 46 patients with possible RBD (the PD-pRBD) and 43 without (the PD-npRBD). PD disease severity, neuropsychological function, overall cognitive function, and various cognitive functions were assessed.
Results: There were significant between-group differences in scores on the Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE), Digit Symbol Test (DST), Trail Making Test-A (TMT-A)-Time, TMT-Trail Making Test-B (TMT-B)-Time, Stroop Color-word Test, Clock Drawing Test (CDT), Boston Naming Test (BNT), Verbal Fluency Test (fruit), etc. ( P  < 0.05).
Interpretation: Patients in the PD-pRBD group had more cognitive impairment.
Competing Interests: The remaining authors have no conflicts of interest or disclosures and none of the authors have any financial associations with commercial entities that were involved with the project.
Databáze: MEDLINE
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