Incidence and Predictive Factors of Hidden Atrial Fibrillation Detected by Implantable Loop Recorder After an Embolic Stroke of Undetermined Source.

Autor: Víctor CU; Electrophysiology Unit. Cardiology Service. Hospital Puerta de Hierro Majadahonda. Spain., Carolina PE; Electrophysiology Unit. Cardiology Service. Hospital Puerta de Hierro Majadahonda. Spain., Jorge TR; Electrophysiology Unit. Cardiology Service. Hospital Puerta de Hierro Majadahonda. Spain., Joaquín CR; Stroke Unit. Neurology Service. Hospital Puerta de Hierro. Majadahonda. Spain., Manuel SG; Electrophysiology Unit. Cardiology Service. Hospital Puerta de Hierro Majadahonda. Spain., Marta CM; Heart failure and Miocardiopathy Unit. Cardiology Service. Hospital Puerta de Hierro. Majadahonda. Spain., José María FV; Electrophysiology Unit. Cardiology Service. Hospital Puerta de Hierro Majadahonda. Spain., Chinh PT; Electrophysiology Unit. Cardiology Service. Hospital Puerta de Hierro Majadahonda. Spain., Javier OM; Critical Care Unit. Cardiology Service. Hospital Puerta de Hierro. Majadahonda. Spain., Susana MS; Ecocardiography Unit. Cardiology Service. Hospital Puerta de Hierro. Majadahonda. Spain., Sánchez Diego J; Electrophysiology Unit. Cardiology Service. Hospital Puerta de Hierro Majadahonda. Spain., Carlos JO; Stroke Unit. Neurology Service. Hospital Puerta de Hierro. Majadahonda. Spain., Ignacio FL; Electrophysiology Unit. Cardiology Service. Hospital Puerta de Hierro Majadahonda. Spain.
Jazyk: angličtina
Zdroj: Journal of atrial fibrillation [J Atr Fibrillation] 2018 Oct 31; Vol. 11 (3), pp. 2078. Date of Electronic Publication: 2018 Oct 31 (Print Publication: 2018).
DOI: 10.4022/jafib.2078
Abstrakt: Background: The term embolic stroke of undetermined source (ESUS) has been defined for patients with ischemic strokes, where neither a cardioembolic nor a non-cardiac source can be detected. These patients may have asymptomatic episodes of atrial fibrillation (AF). Prolonged monitoring with implantable loop recorder (ILR) and daily remote interrogation in patients after an ESUS has shown an incidence of AF of about 25%.
Aims: The main objective of this study was to analyze the incidence and predictive factors of atrial fibrillation in patients with ESUS who underwent an ILR implantation.
Methods: It was a single center study. From June 2013 to January 2017 all consecutive patients with an ESUS, who underwent an ILR implantation searching for hidden AF, were included. Possible predictive factors of AF were also analyzed.
Results: 65 patients were included (mean age 65.4±13.8 years, 55.4% males, mean CHA2DS2VASc score 2.3± 1.5). After a median follow-up of 17.1±10.7 months, AF was detected in 19 (29.2%) of patients. Variables associated with AF were: age > 65 years (HR 9.45 (CI 95% 1.25-71.34); p= 0.02), CHA2DS2VASC score≥2 (HR 4.09 (CI 95% 0.93-17.87); p=0,06), left atrial enlargement (HR 2.29 (CI 95% 0.89-5.91); p=0.08) and presence of Supraventricular premature complex(SVC) on 24-hour Holter (HR 4.05 (CI 95% 1.55-10.57); p = 0.004) A cut-point of 0.15% for SVC was identified to predict AF with a sensitivity and specificity of 88.9 and 90%, respectively. A CHA2DS2VASc score<2 and age<65 years showed a negative predictive value to exclude AF of 91.3% and 96%, respectively.
Conclusion: A high incidence of AF was detected in this population. Age >65 years, LA enlargement, CHA2DS2VASC score≥2 and presence of SVC on 24-hour Holter are predictive factors of AF in patients with ESUS.
Databáze: MEDLINE
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