A Proposed System Toward Standardizing Surgical-Based Treatments for Malignant Pleural Mesothelioma, From the Joint National Cancer Institute-International Association for the Study of Lung Cancer-Mesothelioma Applied Research Foundation Taskforce.

Autor:	Friedberg JS; Division of Thoracic Surgery, University of Maryland School of Medicine, Baltimore, Maryland. Electronic address: jfriedberg@som.umaryland.edu., Culligan MJ; Division of Thoracic Surgery, University of Maryland School of Medicine, Baltimore, Maryland., Tsao AS; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas., Rusch V; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York., Sepesi B; Department of Thoracic and Cardiovascular Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, Texas., Pass HI; Department of Cardiothoracic Surgery, New York University, Langone Medical Center, New York, New York., Bueno R; Thoracic Surgery, Brigham and Women's Hospital, Boston, Massachusetts., Burt B; Department of Surgery, Division of Thoracic Surgery, Baylor College of Medicine, Houston, Texas., Sugarbaker DJ; Department of Surgery, Division of Thoracic Surgery, Baylor College of Medicine, Houston, Texas., de Perrot M; Division of Thoracic Surgery, Toronto General Hospital, Toronto, Ontario, Canada; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada., Adjei AA; Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota., Adusumilli PS; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York., Hirsch FR; Division of Medical Oncology, Mount Sinai Medical Center, New York, New York., Malik SM; Clinical Investigations Branch, Cancer Therapy Evaluation Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Harpole DJ Jr; Division of Cardiothoracic Surgery, Department of Surgery, Duke University, Durham, North Carolina.
Jazyk:	angličtina
Zdroj:	Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer [J Thorac Oncol] 2019 Aug; Vol. 14 (8), pp. 1343-1353. Date of Electronic Publication: 2019 May 25.
DOI:	10.1016/j.jtho.2019.04.029
Abstrakt:	This article is a joint effort arising from a task force formed at a National Cancer Institute-International Association for the Study of Lung Cancer-Mesothelioma Applied Research Foundation Mesothelioma Clinical Trials Planning Meeting, held at the NIH in March 2017. Malignant pleural mesothelioma remains one of the most virulent and recalcitrant malignancies, still considered incurable, and in desperate need of clinical trials in order to make progress for our patients. Although not standard of care, there is compelling evidence that a select subgroup of mesothelioma patients benefit from a surgery-based multimodal approach. As it is not possible to achieve a microscopically complete resection with mesothelioma, there appears to be no role for surgery alone. Thus, it is anticipated that significant strides in the surgery-based treatment of this cancer will require trials that determine which complementary treatments best augment the cytoreductive efficacy of surgery. Although lung-sacrificing surgery for mesothelioma is fairly standardized, approaches to lung-sparing surgery are highly variable and lung sparing surgery is emerging internationally as the dominant extirpative procedure for this cancer. It is not currently possible to rigorously assess the contribution of the adjuvant treatments combined with surgery because of the variability in procedures used to debulk this cancer, the extreme variability of the cancer itself, the variability in patient selection, the variability in treatment of the inevitable recurrence, and even the variability in follow up schedules. This article is an effort to address these problems by suggesting a more uniform approach to the surgical procedure and also proposing a series of data collection forms that could be adopted immediately, with any eye toward collecting the information that will be necessary to facilitate patient selection and determine which aspects of mesothelioma surgery can and should be standardized - with the goal being extension of life while maintaining quality of life as an equal priority. Furthermore, a completely original contribution in this manuscript is the proposal of a grading system that takes the information from the surgical procedure data forms and generates a completeness of resection score. This is the initial effort to establish a common denominator for mesothelioma surgery that will allow for more accurate comparison between surgical series and better assessment of the impact of the treatments combined with surgery. (Crown Copyright © 2019. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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