| Autor: |
Mennechet FJD; a Institut de Génétique Moléculaire de Montpellier , University of Montpellier - CNRS , Montpellier , France., Paris O; a Institut de Génétique Moléculaire de Montpellier , University of Montpellier - CNRS , Montpellier , France., Ouoba AR; a Institut de Génétique Moléculaire de Montpellier , University of Montpellier - CNRS , Montpellier , France.; b UMR 1058, Pathogenesis and Control of Chronic Infections , INSERM - University of Montpellier - Establishment Français du Sang - Centre Hospitalier Universitaire de Montpellier , Montpellier , France.; c Département des sciences et de la recherche clinique , Centre Muraz , Bobo-Dioulasso , Burkina Faso., Salazar Arenas S; a Institut de Génétique Moléculaire de Montpellier , University of Montpellier - CNRS , Montpellier , France., Sirima SB; d Centre National de Recherche et de Formation sur le Paludisme , Ouagadougou , Burkina Faso.; e Groupe de Recherche Action en Santé (GRAS) , Ouagadougou , Burkina Faso., Takoudjou Dzomo GR; f Complexe Hospitalo Universitaire « Le Bon Samaritain » , N'Djamena , Republic of Chad., Diarra A; d Centre National de Recherche et de Formation sur le Paludisme , Ouagadougou , Burkina Faso., Traore IT; c Département des sciences et de la recherche clinique , Centre Muraz , Bobo-Dioulasso , Burkina Faso., Kania D; c Département des sciences et de la recherche clinique , Centre Muraz , Bobo-Dioulasso , Burkina Faso., Eichholz K; a Institut de Génétique Moléculaire de Montpellier , University of Montpellier - CNRS , Montpellier , France., Weaver EA; g University of Nebraska-Lincoln, School of Biological Sciences , Lincoln , NE , USA., Tuaillon E; b UMR 1058, Pathogenesis and Control of Chronic Infections , INSERM - University of Montpellier - Establishment Français du Sang - Centre Hospitalier Universitaire de Montpellier , Montpellier , France., Kremer EJ; a Institut de Génétique Moléculaire de Montpellier , University of Montpellier - CNRS , Montpellier , France. |
| Abstrakt: |
Introduction : Human adenovirus (HAdV)-derived vectors have been used in numerous pre-clinical and clinical trials during the last 40 years. Current research in HAdV-based vaccines focuses on improving transgene immunogenicity and safety. Because pre-existing humoral immunity against HAdV types correlate with reduced vaccine efficacy and safety, many groups are exploring the development of HAdV types vectors with lower seroprevalence. However, global seroepidemiological data are incomplete. Areas covered : The goal of this review is to centralize 65 years of research on (primarily) HAdV epidemiology. After briefly addressing adenovirus biology, we chronical HAdV seroprevalence studies and highlight major milestones. Finally, we analyze data from about 50 studies with respect to HAdVs types that are currently used in the clinic, or are in the developmental pipeline. Expert opinion : Vaccination is among the most efficient tools to prevent infectious disease. HAdV-based vaccines have undeniable potential, but optimization is needed and antivector immunity remains a challenge if the same vectors are to be administrated to different populations. Here, we identify gaps in our knowledge and the need for updated worldwide epidemiological data. |
