Inter-serotype reassortment among epizootic haemorrhagic disease viruses in the United States.

Autor: Wang L; Department of Veterinary Clinical Medicine and the Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Illinois, Urbana, Illinois., Lanka S; Department of Veterinary Clinical Medicine and the Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Illinois, Urbana, Illinois., Cassout D; Department of Veterinary Clinical Medicine and the Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Illinois, Urbana, Illinois., Mateus-Pinilla NE; Illinois Natural History Survey-Prairie Research Institute, University of Illinois Urbana-Champaign, Champaign, Illinois., Li G; Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa., Wilson WC; United States Department of Agriculture, Agricultural Research Service, Arthropod-borne Animal Diseases Research Unit, Manhattan, Kansas., Yoo D; Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois., Shelton P; Illinois Department of Natural Resources, Division of Wildlife Resources, Springfield, Illinois., Fredrickson RL; Department of Veterinary Clinical Medicine and the Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Illinois, Urbana, Illinois.
Jazyk: angličtina
Zdroj: Transboundary and emerging diseases [Transbound Emerg Dis] 2019 Sep; Vol. 66 (5), pp. 1809-1820. Date of Electronic Publication: 2019 Jun 12.
DOI: 10.1111/tbed.13257
Abstrakt: First described in 1955 in New Jersey, epizootic haemorrhagic disease (EHD) causes a severe clinical disease in wild and domestic ruminants worldwide. Epizootic haemorrhagic disease outbreaks occur in deer populations each year from summer to late autumn. The etiological agent is EHD virus (EHDV) which is a double-stranded segmented icosahedral RNA virus. EHD virus utilizes point mutations and reassortment strategies to maintain viral fitness during infection. In 2018, EHDV serotype 2 was predominantly detected in deer in Illinois. Whole genome sequencing was conducted for two 2018 EHDV2 isolates (IL41747 and IL42218) and the sequence analyses indicated that IL42218 was a reassortant between different serotypes whereas IL41747 was a genetically stable strain. Our data suggest that multiple strains contribute to outbreaks each year.
(© 2019 Blackwell Verlag GmbH.)
Databáze: MEDLINE
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