Low-Dose Imaging in a New Preclinical Total-Body PET/CT Scanner.

Autor:	Molinos C; Bruker BioSpin, Preclinical Imaging, Ettlingen, Germany., Sasser T; Bruker BioSpin, Preclinical Imaging, Ettlingen, Germany., Salmon P; Bruker BioSpin, Preclinical Imaging, Ettlingen, Germany., Gsell W; MoSAIC, KU Leuven, Leuven, Belgium., Viertl D; Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne, Switzerland., Massey JC; Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States., Mińczuk K; Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States., Li J; Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States., Kundu BK; Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States., Berr S; Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States., Correcher C; Bruker BioSpin, Preclinical Imaging, Ettlingen, Germany., Bahadur A; Bruker BioSpin, Preclinical Imaging, Ettlingen, Germany., Attarwala AA; Bruker BioSpin, Preclinical Imaging, Ettlingen, Germany., Stark S; Bruker BioSpin, Preclinical Imaging, Ettlingen, Germany., Junge S; Bruker BioSpin, Preclinical Imaging, Ettlingen, Germany., Himmelreich U; MoSAIC, KU Leuven, Leuven, Belgium., Prior JO; Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne, Switzerland., Laperre K; Bruker BioSpin, Preclinical Imaging, Ettlingen, Germany., Van Wyk S; Bruker BioSpin, Preclinical Imaging, Ettlingen, Germany., Heidenreich M; Bruker BioSpin, Preclinical Imaging, Ettlingen, Germany.
Jazyk:	angličtina
Zdroj:	Frontiers in medicine [Front Med (Lausanne)] 2019 May 03; Vol. 6, pp. 88. Date of Electronic Publication: 2019 May 03 (Print Publication: 2019).
DOI:	10.3389/fmed.2019.00088
Abstrakt:	Ionizing radiation constitutes a health risk to imaging scientists and study animals. Both PET and CT produce ionizing radiation. CT doses in pre-clinical in vivo imaging typically range from 50 to 1,000 mGy and biological effects in mice at this dose range have been previously described. [ 18 F]FDG body doses in mice have been estimated to be in the range of 100 mGy for [ 18 F]FDG. Yearly, the average whole body doses due to handling of activity by PET technologists are reported to be 3-8 mSv. A preclinical PET/CT system is presented with design features which make it suitable for small animal low-dose imaging. The CT subsystem uses a X-source power that is optimized for small animal imaging. The system design incorporates a spatial beam shaper coupled with a highly sensitive flat-panel detector and very fast acquisition (<10 s) which allows for whole body scans with doses as low as 3 mGy. The mouse total-body PET subsystem uses a detector architecture based on continuous crystals, coupled to SiPM arrays and a readout based in rows and columns. The PET field of view is 150 mm axial and 80 mm transaxial. The high solid-angle coverage of the sample and the use of continuous crystals achieve a sensitivity of 9% (NEMA) that can be leveraged for use of low tracer doses and/or performing rapid scans. The low-dose imaging capabilities of the total-body PET subsystem were tested with NEMA phantoms, in tumor models, a mouse bone metabolism scan and a rat heart dynamic scan. The CT imaging capabilities were tested in mice and in a low contrast phantom. The PET low-dose phantom and animal experiments provide evidence that image quality suitable for preclinical PET studies is achieved. Furthermore, CT image contrast using low dose scan settings was suitable as a reference for PET scans. Total-body mouse PET/CT studies could be completed with total doses of <10 mGy.
Databáze:	MEDLINE
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