A Double-Blind Placebo Controlled Study of Intranasal Oxytocin's Effect on Emotion Recognition and Visual Attention in Outpatients with Emotional Disorders.

Autor: Rutter LA; Center for Anxiety and Related Disorders, Boston University, 648 Beacon Street, 6 Floor, Boston, MA 02215., Norton DJ; Williams College, 880 Main Street, Williamstown, MA 01267., Brown BS; Center for Anxiety and Related Disorders, Boston University, 648 Beacon Street, 6 Floor, Boston, MA 02215., Brown TA; Center for Anxiety and Related Disorders, Boston University, 648 Beacon Street, 6 Floor, Boston, MA 02215.
Jazyk: angličtina
Zdroj: Cognitive therapy and research [Cognit Ther Res] 2019 Jun; Vol. 43 (3), pp. 523-534. Date of Electronic Publication: 2018 Nov 03.
DOI: 10.1007/s10608-018-9974-x
Abstrakt: The current study used double-blind, placebo-controlled design to examine the effect of intranasal oxytocin (OT) on emotion recognition (ER) and visual attention in 60 outpatients presenting for assessment and treatment of emotional disorders. Our primary hypothesis was that OT would improve recognition of happy faces in depressed participants. The main effect of OT on ER accuracy, speed, and proportion of fixations in the eye region was not significant. Diagnostic group (i.e., presence/absence of a depressive disorder) moderated the effect of OT on ER, but not as expected: OT significantly slowed ER speed for all emotions in participants with anxiety disorders, but did not affect performance in participants with depressive disorders. Depressed participants fixated significantly less in the eye region of sad faces than anxious participants. Before OT can be used to target ER biases, additional research is needed to explicate the differential impact of OT on ER speed in patients with anxiety versus mood disorders.
Competing Interests: Conflict of Interest: This research was supported by Grant MH039096 awarded by the National Institute of Mental Health (Brown) and the Boston University Clara Mayo Fellowship (Rutter).
Databáze: MEDLINE
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