Treatment of atrial fibrillation with concomitant coronary or peripheral artery disease: Results from the outcomes registry for better informed treatment of atrial fibrillation II.

Autor: Inohara T; Duke Clinical Research Institute, Duke University Medical Center, Durham, NC. Electronic address: inohara-circ@umin.ac.jp., Shrader P; Duke Clinical Research Institute, Duke University Medical Center, Durham, NC., Pieper K; Duke Clinical Research Institute, Duke University Medical Center, Durham, NC., Blanco RG; Duke Clinical Research Institute, Duke University Medical Center, Durham, NC., Allen LA; University of Colorado School of Medicine, Aurora, CO., Fonarow GC; Department of Medicine, University of California, Los Angeles, CA., Gersh BJ; Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN., Go AS; Division of Research, Kaiser Permanente Northern California, Oakland, CA., Ezekowitz MD; Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA; Lankenau Medical Center, Wynnewood, PA., Kowey PR; Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA; Lankenau Medical Center, Wynnewood, PA., Reiffel JA; College of Physicians and Surgeons, Columbia University, New York, NY., Naccarelli GV; School of Medicine, Penn State University, Hershey, PA., Chan PS; Department of Cardiovascular Research, St. Luke's Mid America Heart Institute, Kansas City, MO., Mahaffey KW; Stanford Center for Clinical Research, Department of Medicine, Stanford School of Medicine, Stanford, CA., Singer DE; Harvard Medical School and Massachusetts General Hospital, Boston, MA., Freeman JV; Department of Medicine, Yale University School of Medicine, New Haven, CT., Steinberg BA; University of Utah, Salt Lake City, UT., Peterson ED; Duke Clinical Research Institute, Duke University Medical Center, Durham, NC., Piccini JP; Duke Clinical Research Institute, Duke University Medical Center, Durham, NC.
Jazyk: angličtina
Zdroj: American heart journal [Am Heart J] 2019 Jul; Vol. 213, pp. 81-90. Date of Electronic Publication: 2019 Apr 24.
DOI: 10.1016/j.ahj.2019.04.007
Abstrakt: Background: Treatment patterns and outcomes of individuals with vascular disease who have new-onset atrial fibrillation (AF) are not well characterized.
Methods: Among patients with new-onset AF, we analyzed treatment and outcomes in those with or without vascular disease in the ORBIT-AF II registry. Vascular disease was defined as coronary disease with or without myocardial infarction (MI) or revascularization, or peripheral artery disease. The primary outcomes included major adverse cardiovascular or neurological events (MACNE) and major bleeding. Cox proportional hazard models were used to adjust the difference in patient characteristics.
Results: Overall 1920 of 6203 (31.0%) of new-onset AF had vascular disease. In patients with vascular disease, 62.2% of those were treated with direct oral anticoagulants (DOACs) and 23.4% with warfarin. Dual therapy and triple therapy were used in 36.9% and 4.9%, respectively. Vascular disease patients had increased risk of MACNE (adjusted hazard ratio [aHR] 1.83 [95%CIs 1.32-2.55]), but not major bleeding (aHR 1.24 [0.95-1.63]). Among patients with vascular disease, relative to those on warfarin, those treated with DOACs had similar risk for MACNE (aHR 1.20 [0.77-1.87]) but lower risks for bleeding, although it did not reach statistical significance (aHR 0.70 [0.43-1.15]). Concomitant antiplatelet therapy was associated with higher bleeding (aHR 2.27 [1.38-3.73]) with no apparent reduction in MACNE (aHR 1.50 [1.00-2.25]).
Conclusions: Most patients with AF and vascular disease were managed with oral anticoagulation. About half of them were also treated with concomitant antiplatelet therapy, which was associated with increased risk of bleeding, without evidence of improved cardiovascular outcomes.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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