Distinguishing between predictive and incentive value of uncertain gambling-like cues in a Pavlovian autoshaping task.

Autor: Robinson MJF; Department of Psychology, Wesleyan University, 207 High Street, Middletown, CT, 06459, USA; Neuroscience & Behavior Program, Wesleyan University, Middletown, CT, 06459, USA. Electronic address: mjrobinson@wesleyan.edu., Clibanoff C; Department of Psychology, Wesleyan University, 207 High Street, Middletown, CT, 06459, USA; Neuroscience & Behavior Program, Wesleyan University, Middletown, CT, 06459, USA., Freeland CM; Neuroscience & Behavior Program, Wesleyan University, Middletown, CT, 06459, USA; Department of Biology, Wesleyan University, 52 Lawn Avenue, Middletown, CT, 06459, USA., Knes AS; Department of Psychology, Wesleyan University, 207 High Street, Middletown, CT, 06459, USA; Neuroscience & Behavior Program, Wesleyan University, Middletown, CT, 06459, USA., Cote JR; Neuroscience & Behavior Program, Wesleyan University, Middletown, CT, 06459, USA; Department of Biology, Wesleyan University, 52 Lawn Avenue, Middletown, CT, 06459, USA., Russell TI; Department of Psychology, Wesleyan University, 207 High Street, Middletown, CT, 06459, USA; Neuroscience & Behavior Program, Wesleyan University, Middletown, CT, 06459, USA; National Institute of Drug Abuse (NIDA), Baltimore, MD, USA.
Jazyk: angličtina
Zdroj: Behavioural brain research [Behav Brain Res] 2019 Oct 03; Vol. 371, pp. 111971. Date of Electronic Publication: 2019 May 23.
DOI: 10.1016/j.bbr.2019.111971
Abstrakt: The flashing lights and celebratory sounds that dominate slot-machine gambling are believed to promote engagement and motivation to keep playing. However, these cues are often presented in the absence of reward, and previous research suggests that this reward uncertainty, which degrades their predictive value, also increases their incentive value. Here, we used autoshaping to tease apart the impact of reward uncertainty on the predictive and incentive value of a conditioned stimulus (CS) using serial cues. Each CS trial began with the presentation of a predictive CS1, followed by a CS2, holding primarily incentive value, because of its proximity to sucrose reward delivery, under Certain (100%-1) or Uncertain (50%-1- 2-3) reward conditions. Subsequently, we tested the impact of amphetamine and nicotine on cue attraction, and the ability of these cues to either serve as a conditioned reinforcer, or promote motivation for sucrose during a progressive ratio task. Finally, we measured anxiety behavior, and examined its interaction with each cue and uncertainty. Our results suggest that reward uncertainty increases attraction to the incentive CS2 and its ability to trigger motivation and reward-seeking. However, although the CS2 is largely ignored under Certain conditions, both CS1 and CS2 become conditioned reinforcers for both groups. Finally, amphetamine reduced the attraction of the CS1 for both groups but had no effect on the attraction of the CS2. These results suggest that reward uncertainty recruits and increases the incentive value of cues with limited predictive value and highlights the distinction between cue attraction, reward-seeking and conditioned reinforcer properties.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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