The perirhinal cortex supports spatial intertemporal choice stability.

Autor: Kreher MA; McKnight Brain Institute, Department of Neuroscience, University of Florida, Gainesville, FL, United States., Johnson SA; McKnight Brain Institute, Department of Neuroscience, University of Florida, Gainesville, FL, United States., Mizell JM; Department of Psychology, University of Arizona, Tucson, AZ, United States., Chetram DK; McKnight Brain Institute, Department of Neuroscience, University of Florida, Gainesville, FL, United States., Guenther DT; McKnight Brain Institute, Department of Neuroscience, University of Florida, Gainesville, FL, United States., Lovett SD; McKnight Brain Institute, Department of Neuroscience, University of Florida, Gainesville, FL, United States., Setlow B; Department of Psychiatry, University of Florida, Gainesville, FL, United States., Bizon JL; McKnight Brain Institute, Department of Neuroscience, University of Florida, Gainesville, FL, United States., Burke SN; McKnight Brain Institute, Department of Neuroscience, University of Florida, Gainesville, FL, United States; Intittute on Aging, University of Florida, Gainesville, FL, United States., Maurer AP; McKnight Brain Institute, Department of Neuroscience, University of Florida, Gainesville, FL, United States; Department of Biomedical Engineering, United States; Engineering School of Sustainable Infrastructure and Environment, University of Florida, Gainesville, FL, United States. Electronic address: drewmaurer@ufl.edu.
Jazyk: angličtina
Zdroj: Neurobiology of learning and memory [Neurobiol Learn Mem] 2019 Jul; Vol. 162, pp. 36-46. Date of Electronic Publication: 2019 May 21.
DOI: 10.1016/j.nlm.2019.05.002
Abstrakt: In order to optimize outcomes in the face of uncertainty, one must recall past experiences and extrapolate to the future by assigning values to different choice outcomes. This behavior requires an interplay between memory and reward valuation, necessitating communication across many brain regions. At the anatomical nexus of this interplay is the perirhinal cortex (PRC). The PRC is densely connected to the amygdala and orbital frontal cortex, regions that have been implicated in reward-based decision making, as well as the hippocampus. Thus, the PRC could serve as a hub for integrating memory, reward, and prediction. The PRC's role in value-based decision making, however, has not been empirically examined. Therefore, we tested the role of the PRC in a spatial delay discounting task, which allows rats to choose between a 1-s delay for a small food reward and a variable delay for a large food reward, with the delay to the large reward increasing after choice of each large reward and decreasing after each small reward. The rat can therefore adjust the delay by consecutively choosing the same reward or stabilize the delay by alternating between sides. The latter has been shown to occur once the 'temporal cost' of the large reward is established and is a decision-making process termed 'exploitation'. When the PRC was bilaterally inactivated with the GABA(A) agonist muscimol, rats spent fewer trials successfully exploiting to maintain a fixed delay compared to the vehicle control condition. Moreover, PRC inactivation resulted in an increased number of vicarious trial and error (VTE) events at the choice point, where rats had to decide between the two rewards. These behavioral patterns suggest that the PRC is critical for maintaining stability in linking a choice to a reward outcome in the face of a variable cost.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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