Determinants of Viral Resuppression or Persistent Virologic Failure After Initial Failure With Second-Line Antiretroviral Treatment Among Asian Children and Adolescents With HIV.

Autor: Teeraananchai S; HIV Netherlands Australia Thailand Research Collaboration, Thai Red Cross AIDS Research Centre, Bangkok, Thailand., Kerr SJ; HIV Netherlands Australia Thailand Research Collaboration, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.; Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Gandhi M; Division of HIV, Infectious Diseases, and Global Medicine, San Francisco General Hospital, University of California San Francisco., Do VC; Children's Hospital 2, Ho Chi Minh City, Vietnam., Van Nguyen L; National Hospital of Pediatrics, Hanoi, Vietnam., Tran DNH; Children's Hospital 1, Ho Chi Minh City, Vietnam., Kosalaraksa P; Division of Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Thailand., Singtoroj T; TREAT Asia/amfAR-Foundation for AIDS Research, Bangkok, Thailand., Thammajaruk N; HIV Netherlands Australia Thailand Research Collaboration, Thai Red Cross AIDS Research Centre, Bangkok, Thailand., Jupimai T; HIV Netherlands Australia Thailand Research Collaboration, Thai Red Cross AIDS Research Centre, Bangkok, Thailand., Sohn AH; TREAT Asia/amfAR-Foundation for AIDS Research, Bangkok, Thailand.
Jazyk: angličtina
Zdroj: Journal of the Pediatric Infectious Diseases Society [J Pediatric Infect Dis Soc] 2020 Apr 30; Vol. 9 (2), pp. 253-256.
DOI: 10.1093/jpids/piz034
Abstrakt: Of 56 children with perinatally acquired human immunodeficiency virus (HIV) who had been prescribed second-line protease inhibitor-based antiretroviral therapy and had ≥1 previous episode of viral failure (HIV RNA, ≥1000 copies/mL), 46% had ≥1, 34% had ≥2, and 23% had ≥3 consecutive episodes of viral failure during the 2 years of follow-up. Two of these children experienced a major protease inhibitor mutation.
(© The Author(s) 2019. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze: MEDLINE
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