Multielectrode Array (MEA)-Based Detection of Spontaneous Network Activity in Human iPSC-Derived Cortical Neurons.

Autor: Kizner V; CNS Diseases Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, Germany. valeria.kizner@boehringer-ingelheim.com., Fischer S; CNS Diseases Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, Germany., Naujock M; CNS Diseases Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, Germany.
Jazyk: angličtina
Zdroj: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2019; Vol. 1994, pp. 209-216.
DOI: 10.1007/978-1-4939-9477-9_19
Abstrakt: Multielectrode arrays enable the detection of spontaneous cellular network activity, which can be utilized for the characterization of a neuronal culture. Here, we describe the detection of spontaneous neuronal activity in iPSC-derived cortical neurons using a 24-well plate for a multiwall-MEA system.
Databáze: MEDLINE