| Autor: |
Saprin AN, Kalinina EV, Shuliakovskaia TS |
| Jazyk: |
ruština |
| Zdroj: |
Farmakologiia i toksikologiia [Farmakol Toksikol] 1987 May-Jun; Vol. 50 (3), pp. 81-4. |
| Abstrakt: |
It was shown that pretreatment of rats with antioxidants (AO) butylhydroxytoluene and 2-ethyl-6-methyl-3-hydroxypyridine hydrochloride owing to its effect of animal protection against intoxication with diethylnitrosamine (DENA) increases the liver activity of enzymes of stage II metabolism of xenobiotics: glutathione-S-transferase (GST), UDP-glucuronyltransferase (UDP-GT). Administration of DENA (LD50) produced a significant decrease of the activity of GST and UDP-GT as compared with that in intact animals. At the same time its action on the animals pretreated with AO develops against the background of increased activity of these enzymes. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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