| Autor: |
da Costa SG; Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de Bioquímica e Fisiologia de Insetos, Rio de Janeiro, RJ, Brasil., Moraes CDS; Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de Bioquímica e Fisiologia de Insetos, Rio de Janeiro, RJ, Brasil., Bates P; Lancaster University, Faculty of Health and Medicine, Division of Biomedical and Life Sciences, Lancaster, United Kingdom., Dillon R; Lancaster University, Faculty of Health and Medicine, Division of Biomedical and Life Sciences, Lancaster, United Kingdom.; Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro, RJ, Brasil., Genta FA; Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de Bioquímica e Fisiologia de Insetos, Rio de Janeiro, RJ, Brasil.; Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro, RJ, Brasil. |
| Abstrakt: |
The leishmaniases are caused by Leishmania parasites and transmitted through the bites of phlebotomine sand flies. During parasite development inside the vector's midgut, promastigotes move towards the stomodeal valve, a mechanism that is crucial for transmission. It has been reported that the sugar meal acquired by sand flies during feeding between bloodmeals is essential for the development and migration of parasites. We demonstrated that the distribution of Leishmania mexicana parasites was affected by the sugar meals obtained by the sand flies. Promastigote migration towards the cardia region seems to be only partially based on the stimuli provided by sugar molecules. In the absence of sugars, significant amounts of parasites developed in the hindgut. In addition, sugar meals were important for the survival of sand flies, especially during blood digestion, presumably supporting their energy requirements. |
