Carbamazepine-induced DRESS syndrome leading to reversible myocarditis in a child.

Autor: Çetin M; Yüzüncü Yil University, Turkey., Mis MD; Yüzüncü Yil University, Turkey., Karaman K; Yüzüncü Yil University, Turkey., Yavuz ÍH; Yüzüncü Yil University, Turkey., Geylan H; Yüzüncü Yil University, Turkey., Tunçdemir P; Yüzüncü Yil University, Turkey., Demir F; Yüzüncü Yil University, Turkey.
Jazyk: angličtina
Zdroj: Central-European journal of immunology [Cent Eur J Immunol] 2019; Vol. 44 (1), pp. 102-105. Date of Electronic Publication: 2019 Apr 15.
DOI: 10.5114/ceji.2019.83700
Abstrakt: DRESS (drug reaction with eosinophilia and systemic symptoms) syndrome is a rare type of delayed drug hypersensitivity reaction characterised by fever, skin rash, lymphadenopathy, and visceral involvement, which can be life threatening and is a childhood event. An eight-year-old boy was admitted with complaints of extensive rash and fever three weeks after the onset of treatment with carbamazepine for a diagnosis of epilepsy. Fever, as well as patches and plaques with indeterminate limits that tended to merge and were non-blanchable on a widespread erythematous layer, were revealed in physical examination. Extensive cervical, submandibular, and inguinal lymphadenopathy was observed. We present ours as the second case of myocarditis secondary to DRESS syndrome after carbamazepine use in the literature.
Competing Interests: The authors declare no conflict of interest.
Databáze: MEDLINE