Auditory hallucinations in first-episode psychosis: A voxel-based morphometry study.

Autor: Escarti MJ; Department of Psychiatry, Hospital Clinic, University of Valencia, INCLIVA, Valencia, Spain; Department of Psychiatry, Hospital Peset, Av. de Gaspar Aguilar, 90, 46017 Valencia, Spain; Ciber del Área de Salud Mental (CIBERSAM), Spain. Electronic address: mjose.escarti@uchceu.es., Garcia-Marti G; Department of Radiology, Quirón Hospital, Avda. Blasco Ibáñez, 14, 46010 Valencia, Spain; Ciber del Área de Salud Mental (CIBERSAM), Spain., Sanz-Requena R; Department of Radiology, Quirón Hospital, Avda. Blasco Ibáñez, 14, 46010 Valencia, Spain., Marti-Bonmatí L; Department of Radiology, Quirón Hospital, Avda. Blasco Ibáñez, 14, 46010 Valencia, Spain; Biomedical Imaging Research Group (GIBI2^30), Hospital Universitari i Politècnic La Fe, Avda. Fernando Abril Martorell 106, Torre A, 46026, Valencia, Spain., Cabrera B; Barcelona Clinic Schizophrenia Unit, Neurosciences Institute, Hospital Clinic, Barcelona, Spain; Ciber del Área de Salud Mental (CIBERSAM), Spain., Vieta E; Bipolar Disorder Unit, Hospital Clinic of Barcelona, University of Barcelona, Spain; Department of Psychiatry and Clinical Psychobiology, University of Barcelona, IDIBAPS, Barcelona, Spain; Ciber del Área de Salud Mental (CIBERSAM), Spain., Lobo A; Department of Medicine and Psychiatry, Hospital Clinico, University of Zaragoza, Zaragoza, Spain; Instituto de Investigación Sanitaria Aragón (IIS Aragon) y Universidad de Zaragoza, Spain; Ciber del Área de Salud Mental (CIBERSAM), Spain., Castro-Fornieles J; Dept. of Child and Adolescent Psychiatry and Psychology, SGR-489, Institute Clinic of Neurosciences, Hospital Clinic of Barcelona, Spain; Ciber del Área de Salud Mental (CIBERSAM), Spain., González-Pinto A; Department of Psychiatry, Hospital Universitario de Álava (Sede Santiago), EHU/University of the Basque Country, Vitoria, Spain; Ciber del Área de Salud Mental (CIBERSAM), Spain., Cortizo R; Institut de Neuropsiquiatria i Addiccions, Hospital del Mar, Barcelona, Spain., Pina-Camacho L; Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañon, School of Medicine, Universidad Complutense, IiSGM, Madrid, Spain; Ciber del Área de Salud Mental (CIBERSAM), Spain., Parellada M; Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañon, School of Medicine, Universidad Complutense, IiSGM, Madrid, Spain; Ciber del Área de Salud Mental (CIBERSAM), Spain., Bernardo M; Barcelona Clinic Schizophrenia Unit, Neurosciences Institute, Hospital Clinic, Barcelona, Spain; Ciber del Área de Salud Mental (CIBERSAM), Spain., Sanjuan J; Department of Psychiatry, Hospital Clinic, University of Valencia, INCLIVA, Valencia, Spain; Faculty of Medicine, Universitat de València, Avda. Blasco Ibáñez, 15, 46010 Valencia, Spain; Ciber del Área de Salud Mental (CIBERSAM), Spain.
Jazyk: angličtina
Zdroj: Schizophrenia research [Schizophr Res] 2019 Jul; Vol. 209, pp. 148-155. Date of Electronic Publication: 2019 May 18.
DOI: 10.1016/j.schres.2019.05.001
Abstrakt: Background: Auditory hallucinations (AH) are a core symptom of psychosis. The brain abnormalities responsible for AH remain controversial due to inconsistent and conflicting findings across studies, with substantial confounding factors, such as chronicity. Few studies have examined the pathological changes that occur in the gray matter (GM) of patients with first-episode psychosis (FEP) and AH. The present study aims to validate the presence and characteristics of these structural abnormalities in relation to the intensity of psychotic symptoms and AH in a larger homogeneous sample than those of previous studies.
Methods: A magnetic resonance voxel-based morphometric analysis was applied to a group of 215 patients with FEP (93 patients with AH and 122 patients without AH) and 177 healthy controls. The patients were evaluated using the PANSS scale.
Results: Patients with FEP exhibited greater reductions in GM concentrations in the temporal, frontal, cingulate and insular areas than the healthy controls did. No specific differences were found between the patients with FEP and AH and the patients without AH. In addition, total scores on the PANSS were negatively correlated with GM reductions in the FEP group. No correlations were found between the severity of the AH and the GM volumes.
Conclusions: As in previous studies, reductions in the GM concentrations in patients with FEP suggest that alterations are present in the early stages of psychosis, and these alterations are correlated with the severity of the illness. The GM reductions were not found to be related to the presence or severity of AH.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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