Neurological abnormalities in 97 dogs with detectable pituitary masses.

Autor:	Menchetti M; a Department of Veterinary Medical Sciences , University of Bologna , Ozzano dell'Emilia , Italy., De Risio L; b Department of Veterinary Neurology , The Animal Health Trust , Newmarket , Suffolk, UK., Galli G; a Department of Veterinary Medical Sciences , University of Bologna , Ozzano dell'Emilia , Italy., Bruto Cherubini G; c Dick White Referrals, Six Mile Bottom , Cambridgeshire , UK., Corlazzoli D; d Policlinico Veterinario Roma Sud , Rome , Italy., Baroni M; e Clinica Veterinaria Valdinievole , Monsummano Terme , Italy., Gandini G; a Department of Veterinary Medical Sciences , University of Bologna , Ozzano dell'Emilia , Italy.
Jazyk:	angličtina
Zdroj:	The veterinary quarterly [Vet Q] 2019 Dec; Vol. 39 (1), pp. 57-64.
DOI:	10.1080/01652176.2019.1622819
Abstrakt:	Background: Pituitary tumours are common neoplasms of the sellar region in small animals. However, detailed information regarding the spectrum and severity of possible neurological signs are lacking. Objective: To retrospectively describe the neurological abnormalities in a population of dogs with a detectable pituitary mass (DPM) and relate them with the size of the mass and magnetic resonance imaging (MRI) signs of brain compression (BC). Client-owned dogs were included in the study if they had MRI showing a DPM and a detailed neurological examination. The neurological signs were evaluated in relation to the pituitary height/brain ratio (P:B ratio) and the presence/absence of brain compression. Results: Ninety-seven dogs were enrolled. Besides abnormal mentation and behaviour (77%), gait (61%) and cranial nerve abnormalities (44%), other unreported neurological signs observed included postural abnormalities (21%), pain and/or hyperesthesia (25%) and abnormal postural and proprioceptive reactions (49%). The majority of dogs with DPM had signs of BC. The presence of a high pituitary height/brain area and BC represented a risk factor for developing mental status abnormalities. Conclusion: Neurological signs recorded in DPM-affected dogs include not only the typical forebrain signs but also gait disturbances and hyperesthesia. Neurological signs are positively associated with increased P:B ratio and MRI signs of brain compression.
Databáze:	MEDLINE
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