ZNF281 Regulates Cell Proliferation, Migration and Invasion in Colorectal Cancer through Wnt/β-Catenin Signaling.

Autor:	Qin CJ; Department of Gastrointestinal Surgery, Huaihe Hospital of Henan University, Kaifeng, China.; Institute of Clinical Medicine Minimal Invasive, Henan University, Kaifeng, China, hhyyqcj@163.com., Bu PL; Department of Gastrointestinal Surgery, Huaihe Hospital of Henan University, Kaifeng, China., Zhang Q; Department of Gastrointestinal Surgery, Huaihe Hospital of Henan University, Kaifeng, China., Chen JT; Department of Gastrointestinal Surgery, Huaihe Hospital of Henan University, Kaifeng, China., Li QY; Department of Gastrointestinal Surgery, Huaihe Hospital of Henan University, Kaifeng, China., Liu JT; Department of Gastrointestinal Surgery, Huaihe Hospital of Henan University, Kaifeng, China., Dong HC; Department of Gastrointestinal Surgery, Huaihe Hospital of Henan University, Kaifeng, China., Ren XQ; Department of Gastrointestinal Surgery, Huaihe Hospital of Henan University, Kaifeng, China.
Jazyk:	angličtina
Zdroj:	Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology [Cell Physiol Biochem] 2019; Vol. 52 (6), pp. 1503-1516.
DOI:	10.33594/000000104
Abstrakt:	Background/aims: Zinc Finger Protein 281 (ZNF281) was recently identified as a novel oncogene in several human carcinomas. However, the clinical significance of ZNF281 in colorectal cancer (CRC) and the molecular mechanisms by which ZNF281 promotes the growth and metastasis of CRC remain unknown. Methods: ZNF281 expression in CRC tissues was assessed, and the outcomes were analyzed to determine the clinical importance of ZNF281 expression. Cell Transwell assays and a wound healing assay were performed to assess the effects of ZNF281 on CRC cell migration and invasion in vitro. Western blotting was applied to analyze the potential mechanisms. Results: ZNF281 mRNA and protein levels were significantly increased in CRC tissues compared with normal colon tissues, and high ZNF281 expression was associated with advanced T stage, N stage, TNM stage and differentiation. Therefore, ZNF281 expression might be an independent prognostic indicator in CRC patients. Moreover, knockdown of ZNF281 expression suppressed cell proliferation, migration and invasion by inhibiting the Wnt/β-catenin pathway. Conclusion: Our study indicates that ZNF281 plays a critical role in the progression and metastasis of CRC and could represent a potential therapeutic target for CRC. Competing Interests: The authors declare that they have no conflicts of interest. (© Copyright by the Author(s). Published by Cell Physiol Biochem Press.)
Databáze:	MEDLINE
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