Left atrial effective conducting size predicts atrial fibrillation vulnerability in persistent but not paroxysmal atrial fibrillation.
Autor: | Williams SE; Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom., O'Neill L; Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom., Roney CH; Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom., Julia J; Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom., Metzner A; Department of Cardiology, Asklepios Klinik St. Georg, Hamburg, Germany., Reißmann B; Department of Cardiology, Asklepios Klinik St. Georg, Hamburg, Germany., Mukherjee RK; Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom., Sim I; Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom., Whitaker J; Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom., Wright M; Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom., Niederer S; Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom., Sohns C; Department of Cardiology, Asklepios Klinik St. Georg, Hamburg, Germany.; Clinic for Electrophysiology, Herz- und Diabeteszentrum NRW, Ruhr-Universität Bochum, Bad Oeynhausen, Germany., O'Neill M; Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom. |
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Jazyk: | angličtina |
Zdroj: | Journal of cardiovascular electrophysiology [J Cardiovasc Electrophysiol] 2019 Sep; Vol. 30 (9), pp. 1416-1427. Date of Electronic Publication: 2019 Jun 18. |
DOI: | 10.1111/jce.13990 |
Abstrakt: | Background: The multiple wavelets and functional re-entry hypotheses are mechanistic theories to explain atrial fibrillation (AF). If valid, a chamber's ability to support AF should depend upon the left atrial size, conduction velocity (CV), and refractoriness. Measurement of these parameters could provide a new therapeutic target for AF. We investigated the relationship between left atrial effective conducting size (LA Methods and Results: Activation mapping was performed in patients with paroxysmal (n = 21) and persistent AF (n = 18) undergoing pulmonary vein isolation. Parameters used for calculating LA Conclusions: LA (© 2019 The Authors Journal of Cardiovascular ElectrophysiologyPublished by Wiley Periodicals, Inc.) |
Databáze: | MEDLINE |
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