A hypercoagulable state leading to venous limb gangrene associated with occult lung adenocarcinoma.

Autor: Waite MMA; Addenbrooke's Hospital University of Cambridge School of Clinical Medicine Cambridge UK., Martinelli AW; Department of Thoracic Oncology Papworth Hospital NHS Foundation Trust Cambridge UK., Preston SD; Department of Thoracic Oncology Papworth Hospital NHS Foundation Trust Cambridge UK., Gudgin E; Department of Haematology Papworth Hospital NHS Foundation Trust Cambridge UK., Symington E; Department of Haematology Papworth Hospital NHS Foundation Trust Cambridge UK., Rintoul RC; Department of Thoracic Oncology Papworth Hospital NHS Foundation Trust Cambridge UK., Peryt A; Department of Thoracic Surgery Papworth Hospital NHS Foundation Trust Cambridge UK., Coughlin P; Department of Vascular and Endovascular Surgery Addenbrooke's Hospital Cambridge UK., Hayes P; Department of Vascular and Endovascular Surgery Addenbrooke's Hospital Cambridge UK., Gilligan D; Department of Thoracic Oncology Papworth Hospital NHS Foundation Trust Cambridge UK., Besser M; Department of Haematology Papworth Hospital NHS Foundation Trust Cambridge UK.
Jazyk: angličtina
Zdroj: Clinical case reports [Clin Case Rep] 2019 Mar 25; Vol. 7 (5), pp. 888-892. Date of Electronic Publication: 2019 Mar 25 (Print Publication: 2019).
DOI: 10.1002/ccr3.2106
Abstrakt: We report a case of lung adenocarcinoma-associated hypercoagulability leading to venous limb gangrene, managed successfully with argatroban and then dabigatran. Use of idarucizumab permitted diagnostic investigations, leading to targeted antineoplastic therapy with crizotinib, surgical resection with curative intent, and continued survival over 2 years after the index event.
Competing Interests: None declared.
Databáze: MEDLINE
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