Antinociceptive activity of Copaifera officinalis Jacq. L oil and kaurenoic acid in mice.

Autor: Dalenogare DP; Graduated Program in Pharmacology, Federal University of Santa Maria (UFSM), Avenida Roraima, 1000, building 21, room 5207, Santa Maria, RS, 97105-900, Brazil., Ferro PR; Graduated Program in Health Sciences, University of the Extreme South of Santa Catarina (Unesc), Criciúma, SC, 88006-000, Brazil., De Prá SDT; Graduated Program in Health Sciences, University of the Extreme South of Santa Catarina (Unesc), Criciúma, SC, 88006-000, Brazil., Rigo FK; Graduated Program in Health Sciences, University of the Extreme South of Santa Catarina (Unesc), Criciúma, SC, 88006-000, Brazil., de David Antoniazzi CT; Graduated Program in Pharmacology, Federal University of Santa Maria (UFSM), Avenida Roraima, 1000, building 21, room 5207, Santa Maria, RS, 97105-900, Brazil., de Almeida AS; Graduated Program in Pharmacology, Federal University of Santa Maria (UFSM), Avenida Roraima, 1000, building 21, room 5207, Santa Maria, RS, 97105-900, Brazil., Damiani AP; Graduated Program in Health Sciences, University of the Extreme South of Santa Catarina (Unesc), Criciúma, SC, 88006-000, Brazil., Strapazzon G; Graduated Program in Health Sciences, University of the Extreme South of Santa Catarina (Unesc), Criciúma, SC, 88006-000, Brazil., de Oliveira Sardinha TT; Graduated Program in Health Sciences, University of the Extreme South of Santa Catarina (Unesc), Criciúma, SC, 88006-000, Brazil., Galvani NC; Graduated Program in Health Sciences, University of the Extreme South of Santa Catarina (Unesc), Criciúma, SC, 88006-000, Brazil., Boligon AA; Graduated Program in Pharmaceutical Sciences, Federal University of Santa Maria (UFSM), Santa Maria, RS, 97105-900, Brazil., de Andrade VM; Graduated Program in Health Sciences, University of the Extreme South of Santa Catarina (Unesc), Criciúma, SC, 88006-000, Brazil., da Silva Brum E; Graduated Program in Biological Sciences, Toxicological Biochemistry, Federal University of Santa Maria (UFSM), Santa Maria, RS, 97105-900, Brazil., Oliveira SM; Graduated Program in Biological Sciences, Toxicological Biochemistry, Federal University of Santa Maria (UFSM), Santa Maria, RS, 97105-900, Brazil., Trevisan G; Graduated Program in Health Sciences, University of the Extreme South of Santa Catarina (Unesc), Criciúma, SC, 88006-000, Brazil. gabriela.trevisan@ufsm.br.; Graduated Program in Pharmacology, Federal University of Santa Maria (UFSM), Avenida Roraima, 1000, building 21, room 5207, Santa Maria, RS, 97105-900, Brazil. gabriela.trevisan@ufsm.br.
Jazyk: angličtina
Zdroj: Inflammopharmacology [Inflammopharmacology] 2019 Aug; Vol. 27 (4), pp. 829-844. Date of Electronic Publication: 2019 May 16.
DOI: 10.1007/s10787-019-00588-3
Abstrakt: Copaifera officinalis L. possesses traditional uses as an analgesic, anti-inflammatory, and antiseptic. However, until now the antinociceptive effect and the mechanism of action were not described for Copaifera officinalis L. oil and no compound present in this oil was identified to be responsible for its biological effects. The goal of this study was to identify the presence of kaurenoic acid in Copaifera officinalis oil and investigate its antinociceptive effect, mechanism of action, and possible adverse effects in mice. The quantification of kaurenoic acid in Copaifera officinalis oil was done by HPLC-DAD technique. Male and female albino Swiss mice (25-35 g) were used to test the antinociceptive effect of Copaifera officinalis (10 mg/kg, intragastric) or kaurenoic acid (1 mg/kg) in the tail-flick test, intraplantar injection of capsaicin, allyl isothiocyanate (AITC) or complete Freund's adjuvant (CFA). Copaifera officinalis oil and kaurenoic acid caused the antinociceptive effect in the tail-flick test in a dose-dependent manner, and their effect was reversed by naloxone (an opioid antagonist). Copaifera officinalis oil or kaurenoic acid reduced the nociception caused by capsaicin or AITC and produced an anti-allodynic effect in the CFA model (after acute or repeated administration for 7 days). Possible adverse effects were also observed, and non-detectable adverse effect was observed for the intragastric administration of Copaiba officinalis oil or kaurenoic acid and in the same way, the treatments were neither genotoxic nor mutagenic at the doses tested. Thus, Copaiba officinalis oil, and kaurenoic acid possess antinociceptive action without adverse effects.
Databáze: MEDLINE
Externí odkaz: