Effect of green tea extract on arterial stiffness, lipid profile and sRAGE in patients with type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled trial.

Autor: Quezada-Fernández P; Department of Physiology, Pharmacology, Health Sciences University Center, University of Guadalajara , Guadalajara , Mexico.; Department of Physiology, Arterial Stiffness Laboratory, Experimental Therapeutic and Clinic Institute, Health Sciences University Center, University of Guadalajara , Guadalajara , Mexico., Trujillo-Quiros J; Department of Physiology, Pharmacology, Health Sciences University Center, University of Guadalajara , Guadalajara , Mexico.; Department of Physiology, Arterial Stiffness Laboratory, Experimental Therapeutic and Clinic Institute, Health Sciences University Center, University of Guadalajara , Guadalajara , Mexico., Pascoe-González S; Department of Physiology, Pharmacology, Health Sciences University Center, University of Guadalajara , Guadalajara , Mexico.; Department of Physiology, Arterial Stiffness Laboratory, Experimental Therapeutic and Clinic Institute, Health Sciences University Center, University of Guadalajara , Guadalajara , Mexico., Trujillo-Rangel WA; Department of Physiology, Pharmacology, Health Sciences University Center, University of Guadalajara , Guadalajara , Mexico.; Department of Physiology, Arterial Stiffness Laboratory, Experimental Therapeutic and Clinic Institute, Health Sciences University Center, University of Guadalajara , Guadalajara , Mexico., Cardona-Müller D; Department of Physiology, Pharmacology, Health Sciences University Center, University of Guadalajara , Guadalajara , Mexico.; Department of Physiology, Arterial Stiffness Laboratory, Experimental Therapeutic and Clinic Institute, Health Sciences University Center, University of Guadalajara , Guadalajara , Mexico., Ramos-Becerra CG; Department of Physiology, Pharmacology, Health Sciences University Center, University of Guadalajara , Guadalajara , Mexico.; Department of Physiology, Arterial Stiffness Laboratory, Experimental Therapeutic and Clinic Institute, Health Sciences University Center, University of Guadalajara , Guadalajara , Mexico., Barocio-Pantoja M; Department of Physiology, Pharmacology, Health Sciences University Center, University of Guadalajara , Guadalajara , Mexico.; Department of Physiology, Arterial Stiffness Laboratory, Experimental Therapeutic and Clinic Institute, Health Sciences University Center, University of Guadalajara , Guadalajara , Mexico., Rodríguez-de la Cerda M; Department of Physiology, Arterial Stiffness Laboratory, Experimental Therapeutic and Clinic Institute, Health Sciences University Center, University of Guadalajara , Guadalajara , Mexico., Nérida Sánchez-Rodríguez E; Department of Physiology, Pharmacology, Health Sciences University Center, University of Guadalajara , Guadalajara , Mexico., Cardona-Muñóz EG; Department of Physiology, Pharmacology, Health Sciences University Center, University of Guadalajara , Guadalajara , Mexico.; Department of Physiology, Arterial Stiffness Laboratory, Experimental Therapeutic and Clinic Institute, Health Sciences University Center, University of Guadalajara , Guadalajara , Mexico., García-Benavides L; Department of Physiology, Pharmacology, Health Sciences University Center, University of Guadalajara , Guadalajara , Mexico.; Department of Physiology, Arterial Stiffness Laboratory, Experimental Therapeutic and Clinic Institute, Health Sciences University Center, University of Guadalajara , Guadalajara , Mexico., Grover-Páez F; Department of Physiology, Pharmacology, Health Sciences University Center, University of Guadalajara , Guadalajara , Mexico.; Department of Physiology, Arterial Stiffness Laboratory, Experimental Therapeutic and Clinic Institute, Health Sciences University Center, University of Guadalajara , Guadalajara , Mexico.
Jazyk: angličtina
Zdroj: International journal of food sciences and nutrition [Int J Food Sci Nutr] 2019 Dec; Vol. 70 (8), pp. 977-985. Date of Electronic Publication: 2019 May 14.
DOI: 10.1080/09637486.2019.1589430
Abstrakt: Type 2 diabetes mellitus (T2DM) is associated with premature atherosclerosis and arterial stiffening due to the accumulation of advanced glycation end-products in vessel walls. Green tea polyphenols are considered cardio-protective substances. In this randomised double-blind placebo-controlled trial (NCT02627898), we evaluated the effect of Green tea extract on arterial stiffness parameters, lipids, body composition and sRAGE levels. Twenty normotensive patients with T2DM treated with the standard therapy and statins, mean age 53.2 ± 9.4 years and mean BMI 30.1 ± 4.5 kg/m 2 , were randomised to receive a daily dose of 400 mg of green tea extract (polyphenols ≥90%, EGCG ≥45%) or placebo for 12 weeks. Compared to placebo, administration of green tea extract decreased central augmentation index (-3.05 ± 10.8% vs. 6.7 ± 0.1%, p  = .04). These findings suggest that green tea extract could be used as an adjunct to the standard therapy to improve arterial stiffness in T2DM.
Databáze: MEDLINE
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