Cyclopropeniminium Ions Exhibit Unique Reactivity Profiles with Bioorthogonal Phosphines.
| Autor: | Heiss TK, Prescher JA |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | The Journal of organic chemistry [J Org Chem] 2019 Jun 07; Vol. 84 (11), pp. 7443-7448. Date of Electronic Publication: 2019 May 28. |
| DOI: | 10.1021/acs.joc.9b00518 |
| Abstrakt: | We report a new ligation of cyclopropeniminium ions with bioorthogonal phosphines. Cyclopropeniminium scaffolds are sufficiently stable in biological media and, unlike related isomers, react with functionalized phosphines via formal 1,2-addition to a π-system. The ligation can be performed in aqueous solution and is compatible with existing bioorthogonal transformations. Such mutually compatible reactions are useful for multicomponent labeling. |
| Databáze: | MEDLINE |
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