Characterization of hepatitis delta virus strains spreading in Abuja, Nigeria.

Autor: Ifeorah IM; Department of Medical Laboratory Sciences, Faculty of Health Science and Technology, College of Medicine, University of Nigeria Enugu Campus, Enugu, Nigeria., Faleye TOC; Department of Microbiology, Faculty of Science, Ekiti State University, Ado Ekiti, Nigeria.; Department of Virology, College of Medicine, University of Ibadan, Ibadan, Nigeria., Bakarey AS; Institute for Advanced Medical Research & Training, College of Medicine, University of Ibadan, Ibadan, Nigeria., Adewumi OM; Department of Virology, College of Medicine, University of Ibadan, Ibadan, Nigeria., Gerber A; French National Reference Center for Hepatitis B, C, and Delta, Bobigny, France.; Laboratory of Clinical Microbiology, Avicenne Hospital, Bobigny, France., Le Gal F; French National Reference Center for Hepatitis B, C, and Delta, Bobigny, France.; Laboratory of Clinical Microbiology, Avicenne Hospital, Bobigny, France., Adeniji JA; Department of Virology, College of Medicine, University of Ibadan, Ibadan, Nigeria., Gordien E; French National Reference Center for Hepatitis B, C, and Delta, Bobigny, France.; Laboratory of Clinical Microbiology, Avicenne Hospital, Bobigny, France., Onyemelukwe NF; Department of Medical Laboratory Sciences, Faculty of Health Science and Technology, College of Medicine, University of Nigeria Enugu Campus, Enugu, Nigeria.
Jazyk: angličtina
Zdroj: Journal of medical virology [J Med Virol] 2019 Sep; Vol. 91 (9), pp. 1688-1692. Date of Electronic Publication: 2019 Jun 25.
DOI: 10.1002/jmv.25503
Abstrakt: Hepatitis delta virus (HDV) is responsible for the most severe form of liver disease in humans. So far, eight genotypes (HDV-1 to -8) have been individualized worldwide. Little is known about HDV strains that spread in Nigeria. HDV genotyping was performed in 15 anti-HDV positive samples from a cohort of 306 hepatitis B virus (HBV)-infected patients in Abuja (Nigeria). Phylogenetic analyses revealed 90% were HDV-1, two among them clustering with European/Asian HDV-1, the remaining one being HDV-6. It was also found that two members of a couple superinfected with the same HDV strain, were enveloped by two different HBV strains of genotype E.
(© 2019 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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