Paleogenome Reveals Genetic Contribution of Extinct Giant Panda to Extant Populations.

Autor:	Sheng GL; State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences, Wuhan, Hubei 430074, China. Electronic address: glsheng@cug.edu.cn., Basler N; Institute for Biochemistry and Biology, University of Potsdam, Karl-Liebknecht-Strasse 24-25, 14476 Potsdam, Germany., Ji XP; Yunnan Cultural Relics and Archaeology Institute, 15-1, Chunmingli, Chunyuanxiaoqu, Kunming, Yunnan 650118, China; School of Resources, Environment, and Earth Science, Yunnan University, Kunming 650500, China., Paijmans JLA; Institute for Biochemistry and Biology, University of Potsdam, Karl-Liebknecht-Strasse 24-25, 14476 Potsdam, Germany., Alberti F; Institute for Biochemistry and Biology, University of Potsdam, Karl-Liebknecht-Strasse 24-25, 14476 Potsdam, Germany., Preick M; Institute for Biochemistry and Biology, University of Potsdam, Karl-Liebknecht-Strasse 24-25, 14476 Potsdam, Germany., Hartmann S; Institute for Biochemistry and Biology, University of Potsdam, Karl-Liebknecht-Strasse 24-25, 14476 Potsdam, Germany., Westbury MV; Institute for Biochemistry and Biology, University of Potsdam, Karl-Liebknecht-Strasse 24-25, 14476 Potsdam, Germany., Yuan JX; State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences, Wuhan, Hubei 430074, China., Jablonski NG; Department of Anthropology, The Pennsylvania State University, 409 Carpenter Building, University Park, PA 16802, USA., Xenikoudakis G; Institute for Biochemistry and Biology, University of Potsdam, Karl-Liebknecht-Strasse 24-25, 14476 Potsdam, Germany., Hou XD; State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences, Wuhan, Hubei 430074, China., Xiao B; State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences, Wuhan, Hubei 430074, China., Liu JH; Yunnan Cultural Relics and Archaeology Institute, 15-1, Chunmingli, Chunyuanxiaoqu, Kunming, Yunnan 650118, China., Hofreiter M; Institute for Biochemistry and Biology, University of Potsdam, Karl-Liebknecht-Strasse 24-25, 14476 Potsdam, Germany., Lai XL; State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences, Wuhan, Hubei 430074, China., Barlow A; Institute for Biochemistry and Biology, University of Potsdam, Karl-Liebknecht-Strasse 24-25, 14476 Potsdam, Germany. Electronic address: axel.barlow.ab@gmail.com.
Jazyk:	angličtina
Zdroj:	Current biology : CB [Curr Biol] 2019 May 20; Vol. 29 (10), pp. 1695-1700.e6. Date of Electronic Publication: 2019 May 09.
DOI:	10.1016/j.cub.2019.04.021
Abstrakt:	Historically, the giant panda was widely distributed from northern China to southwestern Asia [1]. As a result of range contraction and fragmentation, extant individuals are currently restricted to fragmented mountain ranges on the eastern margin of the Qinghai-Tibet plateau, where they are distributed among three major population clusters [2]. However, little is known about the genetic consequences of this dramatic range contraction. For example, were regions where giant pandas previously existed occupied by ancestors of present-day populations, or were these regions occupied by genetically distinct populations that are now extinct? If so, is there any contribution of these extinct populations to the genomes of giant pandas living today? To investigate these questions, we sequenced the nuclear genome of an ∼5,000-year-old giant panda from Jiangdongshan, Tengchong County in Yunnan Province, China. We find that this individual represents a genetically distinct population that diverged prior to the diversification of modern giant panda populations. We find evidence of differential admixture with this ancient population among modern individuals originating from different populations as well as within the same population. We also find evidence for directional gene flow, which transferred alleles from the ancient population into the modern giant panda lineages. A variable proportion of the genomes of extant individuals is therefore likely derived from the ancient population represented by our sequenced individual. Although extant giant panda populations retain reasonable genetic diversity, our results suggest that this represents only part of the genetic diversity this species harbored prior to its recent range contractions. (Copyright © 2019 Elsevier Ltd. All rights reserved.)
Databáze:	MEDLINE
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