High amyloid burden is associated with fewer specific words during spontaneous speech in individuals with subjective cognitive decline.

Autor: Verfaillie SCJ; Department of Neurology and Alzheimer Center, Amsterdam University Medical Center, location VUmc, Vrije Universiteit, de Boelelaan 1118, 1081HZ, Amsterdam, the Netherlands; Department of Radiology & Nuclear Medicine, Amsterdam University Medical Center, location VUmc, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam, the Netherlands. Electronic address: s.verfaillie@vumc.nl., Witteman J; Leiden University Centre for Linguistics, Leiden, the Netherlands; Leiden Institute for Brain and Cognition, Leiden, the Netherlands., Slot RER; Department of Neurology and Alzheimer Center, Amsterdam University Medical Center, location VUmc, Vrije Universiteit, de Boelelaan 1118, 1081HZ, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam, the Netherlands., Pruis IJ; Department of Neurology and Alzheimer Center, Amsterdam University Medical Center, location VUmc, Vrije Universiteit, de Boelelaan 1118, 1081HZ, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam, the Netherlands., Vermaat LEW; Department of Neurology and Alzheimer Center, Amsterdam University Medical Center, location VUmc, Vrije Universiteit, de Boelelaan 1118, 1081HZ, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam, the Netherlands., Prins ND; Department of Neurology and Alzheimer Center, Amsterdam University Medical Center, location VUmc, Vrije Universiteit, de Boelelaan 1118, 1081HZ, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam, the Netherlands., Schiller NO; Leiden University Centre for Linguistics, Leiden, the Netherlands; Leiden Institute for Brain and Cognition, Leiden, the Netherlands., van de Wiel M; Department of Epidemiology & Biostatistics, Amsterdam University Medical Center, location VUmc, Amsterdam, the Netherlands., Scheltens P; Department of Neurology and Alzheimer Center, Amsterdam University Medical Center, location VUmc, Vrije Universiteit, de Boelelaan 1118, 1081HZ, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam, the Netherlands., van Berckel BNM; Department of Radiology & Nuclear Medicine, Amsterdam University Medical Center, location VUmc, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam, the Netherlands., van der Flier WM; Department of Radiology & Nuclear Medicine, Amsterdam University Medical Center, location VUmc, Amsterdam, the Netherlands; Department of Epidemiology & Biostatistics, Amsterdam University Medical Center, location VUmc, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam, the Netherlands., Sikkes SAM; Department of Radiology & Nuclear Medicine, Amsterdam University Medical Center, location VUmc, Amsterdam, the Netherlands; Department of Epidemiology & Biostatistics, Amsterdam University Medical Center, location VUmc, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam, the Netherlands.
Jazyk: angličtina
Zdroj: Neuropsychologia [Neuropsychologia] 2019 Aug; Vol. 131, pp. 184-192. Date of Electronic Publication: 2019 May 07.
DOI: 10.1016/j.neuropsychologia.2019.05.006
Abstrakt: Self-perceived word-finding difficulties are common in aging individuals as well as in Alzheimer's Disease (AD). Language and speech deficits are difficult to objectify with neuropsychological assessments. We therefore aimed to investigate whether amyloid, an early AD pathological hallmark, is associated with speech-derived semantic complexity. We included 63 individuals with subjective cognitive decline (age 64 ± 8, MMSE 29 ± 1), with amyloid status (positron emission tomography [PET] scans n = 59, or Aβ 1-42 cerebrospinal fluid [CSF] n = 4). Spontaneous speech was recorded using three open-ended tasks (description of cookie theft picture, abstract painting and a regular Sunday), transcribed verbatim and subsequently, linguistic parameters were extracted using T-scan computational software, including specific words (content words, frequent, concrete and abstract nouns, and fillers), lexical complexity (lemma frequency, Type-Token-Ratio) and syntactic complexity (Developmental Level scale). Nineteen individuals (30%) had high levels of amyloid burden, and there were no differences between groups on conventional neuropsychological tests. Using multinomial regression with linguistic parameters (in tertiles), we found that high amyloid burden is associated with fewer concrete nouns (OR middle (95%CI): 7.6 (1.4-41.2), OR lowest : 6.7 (1.2-37.1)) and content words (OR lowest : 6.3 (1.0-38.1). In addition, we found an interaction for education between high amyloid burden and more abstract nouns. In conclusion, high amyloid burden was modestly associated with fewer specific words, but not with syntactic complexity, lexical complexity or conventional neuropsychological tests, suggesting that subtle spontaneous speech deficits might occur in preclinical AD.
(Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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