Phylogeographical and cross-species transmission dynamics of SAT1 and SAT2 foot-and-mouth disease virus in Eastern Africa.

Autor: Omondi G; Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota., Alkhamis MA; Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota.; Department of Epidemiology and Biostatistics, Faculty of Public Health, Health Sciences Center, Kuwait University, Kuwait, Kuwait., Obanda V; Veterinary Services Department, Kenya Wildlife Service, Nairobi, Kenya., Gakuya F; Veterinary Services Department, Kenya Wildlife Service, Nairobi, Kenya., Sangula A; Foot-and-Mouth Disease Laboratory, Nairobi, Kenya., Pauszek S; Plum Island Animal Disease Center, Foreign Animal Disease Research Unit, USDA, Orient Point, New York., Perez A; Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota., Ngulu S; Ol Pejeta Conservancy, Nanyuki, Kenya., van Aardt R; Ol Pejeta Conservancy, Nanyuki, Kenya., Arzt J; Plum Island Animal Disease Center, Foreign Animal Disease Research Unit, USDA, Orient Point, New York., VanderWaal K; Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota.
Jazyk: angličtina
Zdroj: Molecular ecology [Mol Ecol] 2019 Jun; Vol. 28 (11), pp. 2903-2916. Date of Electronic Publication: 2019 May 31.
DOI: 10.1111/mec.15125
Abstrakt: Understanding the dynamics of foot-and-mouth disease virus (FMDV), an endemic and economically constraining disease, is critical in designing control programmes in Africa. This study investigates the evolutionary epidemiology of SAT1 and SAT2 FMDV in Eastern Africa, as well as between cattle and wild African buffalo. Bayesian phylodynamic models were used to analyse SAT1 and SAT2 VP1 gene segments collected between 1975 and 2016, focusing on the SAT1 and SAT2 viruses currently circulating in Eastern Africa. The root state posterior probabilities inferred from our analyses suggest Zimbabwe as the ancestral location for SAT1 currently circulating in Eastern Africa (p = 0.67). For the SAT2 clade, Kenya is inferred to be the ancestral location for introduction of the virus into other countries in Eastern Africa (p = 0.72). Salient (Bayes factor >10) viral dispersal routes were inferred from Tanzania to Kenya, and from Kenya to Uganda for SAT1 and SAT2, respectively. Results suggest that cattle are the source of the SAT1 and SAT2 clades currently circulating in Eastern Africa. In addition, our results suggest that the majority of SAT1 and SAT2 in livestock come from other livestock rather than wildlife, with limited evidence that buffalo serve as reservoirs for cattle. Insights from the present study highlight the role of cattle movements and anthropogenic activities in shaping the evolutionary history of SAT1 and SAT2 in Eastern Africa. While the results may be affected by inherent limitations of imperfect surveillance, our analysis elucidates the dynamics between host species in this region, which is key to guiding disease intervention activities.
(© 2019 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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