Serum Neuron-specific Enolase and S100 Calcium-binding Protein B in Pediatric Diabetic Ketoacidosis

Autor: Elshorbagy HH; Menoufia University Faculty of Medicine, Departments of Pediatrics and Pediatric Neurology, Shebeen Elkom, Egypt; Alhada and Taif Armed forces Hospitals, Departments of Pediatrics and Pediatric Neurology, Taif, Saudi Arabia, Barseem NF; Menofia University Faculty of Medicine, Department of Pediatrics, Shebeen Elkom, Egypt, Elsadek AE; Benha University Faculty of Medicine, Department of Pediatrics, Al Obour, Egypt, Al-shokary AH; Benha University Faculty of Medicine, Department of Pediatrics, Al Obour, Egypt, Maksoud YHA; Benha University Faculty of Medicine, Department of Pediatrics, Al Obour, Egypt, Abdulsamea SE; Benha University Faculty of Medicine, Department of Pediatrics, Al Obour, Egypt, Talaat IM; Ain Shams University Faculty of Medicine, Department of Pediatrics, Cairo, Egypt, Suliman HA; Benha University Faculty of Medicine, Department of Pediatrics, Al Obour, Egypt, Kamal NM; Cairo University Faculty of Medicine, Departments of Pediatrics and Pediatric Hepatology, Cairo, Egypt; Alhada Armed forces Hospital, Clinics of Pediatric Hepatology and Gastroenterology, Taif, Saudi Arabia, Abdelghani WE; Benha University Faculty of Medicine, Department of Pediatrics, Al Obour, Egypt, Azab SM; Al-Azhar University Faculty of Medicine, Department of Pediatrics, El-Khalifa, Egypt, El Din DMN; Benha University Faculty of Medicine, Department of Clinical Pathology, Benha, Egypt
Jazyk: angličtina
Zdroj: Journal of clinical research in pediatric endocrinology [J Clin Res Pediatr Endocrinol] 2019 Nov 22; Vol. 11 (4), pp. 374-387. Date of Electronic Publication: 2019 May 09.
DOI: 10.4274/jcrpe.galenos.2019.2018.0280
Abstrakt: Objective: Neuron-specific enolase (NSE) and S100 calcium-binding protein B (S100B) are markers of different neurological disorders. The aim was to investigate the relationship between NSE and S100B serum concentrations and the severity of diabetic ketoacidosis (DKA) in diabetic children.
Methods: Eighty children with DKA, 40 with type 1 diabetes mellitus (T1DM) without DKA and 40 healthy controls were enrolled. Severity of DKA was assessed according to blood pH and bicarbonate concentration. Serum NSE and S100B were measured in all participants. In the DKA group serum NSE and S100B were measured at three time points, at admission and at 12 hours and 24 hours after starting treatment.
Results: Children with DKA showed significantly higher serum levels of NSE at all time points compared to children with T1DM without DKA and controls (p<0.01), while serum S100B concentrations did not differ between the three cohorts. Children with T1DM but without DKA also had significantly higher serum levels of NSE (p<0.01) compared to healthy controls. Patients with low Glasgow Coma Scale score (GCSS) and those with moderate and severe DKA had significantly higher levels of NSE at all time points (p<0.01 for each) compared to patients with normal GCSS and those with mild DKA. No significant differences were found in serum S100B levels according to the severity of DKA and GCS (p>0.05). Younger age, lower GCSS, higher glucose and HbA1c, lower pH and lower serum bicarbonate were the risk factors associated with elevated NSE.
Conclusion: Serum NSE is elevated in all patients with type 1 DM and, in patients with DKA, correlates with severity of DKA. However, serum S100B concentration did not differ between T1DM with or without DKA and healthy controls.
Databáze: MEDLINE
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