| Autor: |
Felton MA; a MedStar Health Department of Medicine , Baltimore , MD , USA., Jarrett JB; b University of Illinois at Chicago College of Pharmacy , Chicago , IL , USA., Hoffmaster R; c UPMC St. Margaret Department of Medical Education , Pittsburgh , PA , USA., D'Amico FJ; d UPMC Palliative and Supportive Institute (PSI) , Pittsburgh , PA , USA., Sakely H; e Department of Mathematics and Computer Science at Duquesne University , Pittsburgh , PA , USA., Pruskowski J; d UPMC Palliative and Supportive Institute (PSI) , Pittsburgh , PA , USA. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of pain & palliative care pharmacotherapy [J Pain Palliat Care Pharmacother] 2018 Jun - Sep; Vol. 32 (2-3), pp. 141-148. |
| DOI: |
10.1080/15360288.2018.1513434 |
| Abstrakt: |
Antipsychotics are frequently used for treatment of delirium, although little evidence exists that they improve delirium outcomes. Our objective was to evaluate haloperidol (HAL) compared to non-haloperidol antipsychotics (NHAP) or no pharmacologic treatment (NP) in the management of delirium in older adults under the care of a palliative care consult service across a large, integrated health care system. A retrospective chart review examined data from September 2014-September 2015. All hospitalized patients ≥65 years old with a diagnosis of delirium during palliative care consultation were included (n = 304). Primary outcome was length of stay after delirium diagnosis. Secondary outcomes included delirium symptom length, sedation, and QTc prolongation. Univariate statistical tests, analysis of covariance, and multiple regression methods were used to compare groups. Post-delirium length of stay in the HAL, NHAP, and NP groups were 8.5, 7.0, and 6.8 days, respectively (p = 0.19). Delirium duration in the HAL, NHAP, and NP groups were 6.7, 6.0, and 4.9 days, respectively (p = 0.05). Safety outcomes were statistically different than the reference group (NHAP). Congruent with existing literature in other generalized patient populations, no significant difference in post-delirium length of stay existed in geriatric, palliative care population. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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