| Autor: |
Garms BC; Institute of Chemistry, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil. b.garms@uq.edu.au., Borges FA; Institute of Chemistry, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil., de Barros NR; Institute of Chemistry, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil., Marcelino MY; School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil., Leite MN; School of Medicine, São Paulo University (USP), Ribeirão Preto, São Paulo, Brazil., Del Arco MC; School of Pharmaceutical Science, São Paulo University (USP), Ribeirão Preto, São Paulo, Brazil., de Souza Salvador SL; School of Pharmaceutical Science, São Paulo University (USP), Ribeirão Preto, São Paulo, Brazil., Pegorin GS; School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil., Oliveira KSM; Faculty of Agricultural Sciences, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil., Frade MAC; School of Medicine, São Paulo University (USP), Ribeirão Preto, São Paulo, Brazil., Herculano RD; School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil. rond@fcfar.unesp.br. |
| Abstrakt: |
Natural rubber latex (NRL) is a natural polymer which has arisen large interest in the biomedical field, mostly, due to its ability to facilitate angiogenesis and therefore, tissue repair. Moxifloxacin (MXF) is a broad-spectrum antibiotic orally administrated. Considering the biological properties of the NRL and its ability to deliver a wide range of compounds, the present study aimed to develop a novel device for infected chronic wound treatment. MXF-loaded NRL was obtained by a casting method. The results demonstrated that the incorporation of MXF in NRL did not promote any molecular interaction, preserving the integrity of the compounds. The mechanical properties of the biomaterial did not show any significant change, indicating enough elasticity for dermal application. The microbiological assays confirmed the ability of the polymer to deliver the drug without influencing its pharmacological properties. Moreover, it has expressed activity against major bacterial strains presented in wound infections. Finally, the biomaterial shown biocompatibility from the in vitro study. Thus, the present work has shown that MXF-loaded NRL membrane is a promising biomaterial to infected wound treatment. |
