Chronic kidney disease and HIV in the era of antiretroviral treatment: findings from a 10-year cohort study in a west African setting.

Autor: Kaboré NF; Department of Clinical Research, Centre MURAZ, Nongodo Firmin KABORE, Bobo-Dioulasso, BP 808, Burkina Faso. firmin.kabore@centre-muraz.bf., Poda A; Department of Infectious Diseases, University Hospital Souro Sanou, Bobo-Dioulasso, Burkina Faso.; Institut Supérieur des Sciences de la Santé, Université Nazi Boni, Bobo-Dioulasso, Burkina Faso., Zoungrana J; Department of Infectious Diseases, University Hospital Souro Sanou, Bobo-Dioulasso, Burkina Faso.; Institut Supérieur des Sciences de la Santé, Université Nazi Boni, Bobo-Dioulasso, Burkina Faso., Da O; Biochemistry Department, University Hospital Souro Sanou, Bobo-Dioulasso, Burkina Faso., Ciaffi L; Unité Mixte Internationale 233, Institut de Recherche pour le Développement, U1175-Inserm, University of Montpellier, Montpellier, France., Semdé A; Department of nephrology, University Hospital Souro Sanou, Bobo-Dioulasso, Burkina Faso., Yaméogo I; Department of Infectious Diseases, University Hospital Souro Sanou, Bobo-Dioulasso, Burkina Faso., Sawadogo AB; Department of Infectious Diseases, University Hospital Souro Sanou, Bobo-Dioulasso, Burkina Faso., Delaporte E; Unité Mixte Internationale 233, Institut de Recherche pour le Développement, U1175-Inserm, University of Montpellier, Montpellier, France.; Department of Infectious Diseases, University Hospital of Montpellier, Montpellier, France., Meda N; Université Ouaga 1 Pr Joseph Ki-Zerbo, Ouagadougou, Burkina Faso., Limou S; Centre de Recherche en Transplantation et Immunologie (CRTI) UMR1064, Inserm, Université de Nantes, Nantes, France.; Institut de Transplantation en Urologie-Néphrologie (ITUN), Nantes University Hospital, Nantes, France.; Ecole Centrale de Nantes, Nantes, France.; Basic Research Laboratory, NIH/NCI, Frederick National Laboratory, Leidos Biomedical Research, Inc, Frederick, MD, USA., Cournil A; Unité Mixte Internationale 233, Institut de Recherche pour le Développement, U1175-Inserm, University of Montpellier, Montpellier, France.
Jazyk: angličtina
Zdroj: BMC nephrology [BMC Nephrol] 2019 May 07; Vol. 20 (1), pp. 155. Date of Electronic Publication: 2019 May 07.
DOI: 10.1186/s12882-019-1335-9
Abstrakt: Background: It has been reported that people living with HIV in West Africa exhibited the highest risks for chronic kidney disease (CKD) in the world. Here, we aimed at determining the CKD frequency and changes in kidney function during antiretroviral treatment (ART) in a large cohort of HIV-patients followed in Burkina Faso.
Methods: We included ART-naive adults who initiated ART at the Day Care Unit of the Souro Sanou University Hospital between 01/01/2007 and 12/31/2016. We assessed the estimated glomerular filtration rate (eGFR) by serum creatinine using the Modification of Diet in Renal Disease (MDRD) equation. Following the K/DOQI recommendations, CKD was defined as eGFR < 60 ml/min/1.73m 2 at two consecutive measurements at least 3 months apart. The factors associated with eGFR decline or CKD were identified by mixed linear regression and Cox regression, respectively.
Results: Three thousand, one hundred and thirty-eight patients (72% women) were followed for a median (IQR) of 4.5(2.2-6.9) years. At baseline, median eGFR (IQR) was 110.7(94.4-128.4) ml/min/1.73m 2 and 93 (3%) patients exhibited eGFR < 60 ml/min/1.73m 2 . The lowest-performing progressions of eGFR during the first year of ART were observed in patients with 40-49 yr. age range (- 8.3[- 11.7;-5.0] ml/min/1.73m 2 , p < 0.001), age ≥ 50 yr. (- 6.2[- 10.7;-1.8] ml/min/1.73m 2 , p = 0.006) and high blood pressure (HBP) (- 28.4[- 46.9;-9.9] ml/min/1.73m 2 , p = 0.003) at ART initiation. Regarding the ART exposure in patients with normal baseline eGFR, zidovudine (AZT) with protease inhibitor (PI) (- 4.7[- 7.7;-1.6] ml/min/1.73m 2 , p = 0.002), tenofovir (TDF) + PI (- 13.1[- 17.4;-8.7] ml/min/1.73m 2 , p < 0.001), TDF without PI (- 3.2[- 5.0;-1.4] ml/min/1.73m 2 , p < 0.001), stavudine (d4T) + PI (- 8.5[- 14.6-2.4] ml/min/1.73m 2 , p = 0.006) and d4T without PI (- 5.0[- 7.6-2.4] ml/min/1.73m 2 , p < 0.001) were associated with poorer eGFR progression. The prevalence of CKD was 0.5% and the incidence was 1.9 [1.3; 2.7] cases/1000 person-years. The risk of CKD was higher in patients with HBP (4.3[1.8;9.9], p = 0.001), 40-49 yr. patients (4.2[1.6;11.2], p = 0.004), ≥50 yr. patients (4.5[1.5;14.1], p = 0.009) and patients exposed to abacavir (ABC) or didanosine (ddI) based ART (13.1[4.0;42.9], p < 0.001).
Conclusions: Our findings do not confirm the high risk of CKD reported in previous studies of West Africans with HIV, but support the recommendations for early initiation of ART and close kidney function monitoring in patients with HBP or aged ≥40 yr.
Databáze: MEDLINE
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