Zika Virus Causes Acute Infection and Inflammation in the Ovary of Mice Without Apparent Defects in Fertility.

Autor:	Caine EA; Departments of Medicine, Molecular Microbiology, Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri., Scheaffer SM; Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri., Broughton DE; Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri., Salazar V; Departments of Medicine, Molecular Microbiology, Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri., Govero J; Departments of Medicine, Molecular Microbiology, Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri., Poddar S; Departments of Medicine, Molecular Microbiology, Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri., Osula A; Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri., Halabi J; Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri., Skaznik-Wikiel ME; Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora., Diamond MS; Departments of Medicine, Molecular Microbiology, Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri., Moley KH; Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2019 Nov 06; Vol. 220 (12), pp. 1904-1914.
DOI:	10.1093/infdis/jiz239
Abstrakt:	Background: Zika virus (ZIKV) has become a global concern because infection of pregnant mothers was linked to congenital birth defects. Zika virus is unique from other flaviviruses, because it is transmitted vertically and sexually in addition to by mosquito vectors. Prior studies in mice, nonhuman primates, and humans have shown that ZIKV targets the testis in males, resulting in persistent infection and oligospermia. However, its effects on the corresponding female gonads have not been evaluated. Methods: In this study, we assessed the effects of ZIKV on the ovary in nonpregnant mice. Results: During the acute phase, ZIKV productively infected the ovary causing accumulation of CD4+ and virus-specific CD8+ T cells. T cells protected against ZIKV infection in the ovary, as higher viral burden was measured in CD8-/- and TCRβδ-/- mice. Increased cell death and tissue inflammation in the ovary was observed during the acute phase of infection, but this normalized over time. Conclusions: In contrast to that observed with males, minimal persistence and no long-term consequences of ZIKV infection on ovarian follicular reserve or fertility were demonstrated in this model. Thus, although ZIKV replicates in cells of the ovary and causes acute oophoritis, there is rapid resolution and no long-term effects on fertility, at least in mice. (© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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