Short Enantioselective Formal Synthesis of (-)-Platencin.

Autor: Defieber C; The Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering California Institute of Technology, 1200 E California Blvd. MC 101-20, Pasadena, CA 91125, USA., Mohr JT; The Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering California Institute of Technology, 1200 E California Blvd. MC 101-20, Pasadena, CA 91125, USA.; Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, IL 60607, USA., Grabovyi GA; Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, IL 60607, USA., Stoltz BM; The Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering California Institute of Technology, 1200 E California Blvd. MC 101-20, Pasadena, CA 91125, USA.
Jazyk: angličtina
Zdroj: Synthesis [Synthesis (Stuttg)] 2018 Nov; Vol. 50 (22), pp. 4359-4368. Date of Electronic Publication: 2018 Jul 23.
DOI: 10.1055/s-0037-1610437
Abstrakt: A short enantioselective formal synthesis of the antibiotic natural product platencin is reported. Key steps in the synthesis include enantioselective decarboxylation alkylation, aldehyde/olefin radical cyclization, and regioselective aldol cyclization.
Databáze: MEDLINE