Dronedarone (a multichannel blocker) enhances the anticonvulsant potency of lamotrigine, but not that of lacosamide, pregabalin and topiramate in the tonic-clonic seizure model in mice.
Autor: | Sawicka KM; Department of Internal Medicine in Nursing, Medical University of Lublin, Lublin, Poland; Department of Pathophysiology, Medical University of Lublin, Lublin, Poland., Florek-Łuszczki M; Department of Medical Anthropology, Institute of Rural Health, Lublin, Poland., Wawryniuk A; Department of Internal Medicine in Nursing, Medical University of Lublin, Lublin, Poland., Daniluk J; Department of Internal Medicine in Nursing, Medical University of Lublin, Lublin, Poland., Wróblewska-Łuczka P; Department of Pathophysiology, Medical University of Lublin, Lublin, Poland., Chmielewski J; Institute of Environmental Protection - National Research Institute in Warsaw, Poland., Karwan S; Regional Specialized Children's Hospital, Olsztyn, Poland., Łuszczki JJ; Department of Pathophysiology, Medical University of Lublin, Lublin, Poland. Electronic address: jluszczki@yahoo.com. |
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Jazyk: | angličtina |
Zdroj: | Epilepsy research [Epilepsy Res] 2019 Aug; Vol. 154, pp. 62-68. Date of Electronic Publication: 2019 Apr 22. |
DOI: | 10.1016/j.eplepsyres.2019.04.007 |
Abstrakt: | Accumulating experimental evidence indicates that some recently licensed antiarrhythmic drugs, including dronedarone (a multichannel blocker) play a crucial role in initiation of seizures in both, in vivo and in vitro studies. Some of these antiarrhythmic drugs elevate the threshold for maximal electroconvulsions and enhance the anticonvulsant potency of classical antiepileptic drugs in preclinical studies. This study was aimed at determining the influence of dronedarone (an antiarrhythmic drug) on the anticonvulsant potency of four novel antiepileptic drugs (lacosamide, lamotrigine, pregabalin and topiramate) in the maximal electroshock-induced seizure model in mice. To exclude any potential pharmacokinetic contribution of dronedarone to the observed interactions, total brain concentrations of antiepileptic drugs were measured. Dronedarone (50 mg/kg, i.p.) significantly enhanced the anticonvulsant potency of lamotrigine, by reducing its ED (Copyright © 2019 Elsevier B.V. All rights reserved.) |
Databáze: | MEDLINE |
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