The association between novel clinical factors and gastrointestinal bleeding among patients supported with continuous-flow left ventricular assist device therapy.

Autor: Thohan V; Aurora Cardiovascular Services, Aurora Health Care, Milwaukee, Wisconsin., Shi Y; Center for Integrative Research on Cardiovascular Aging (CIRCA), Aurora Research Institute, Aurora Health Care, Milwaukee, Wisconsin., Rappelt M; Center for Integrative Research on Cardiovascular Aging (CIRCA), Aurora Research Institute, Aurora Health Care, Milwaukee, Wisconsin., Yousefzai R; Department of Cardiology, Brown University, Providence, Rhode Island., Sulemanjee NZ; Aurora Cardiovascular Services, Aurora Health Care, Milwaukee, Wisconsin., Hastings TE; Aurora Cardiovascular Services, Aurora Health Care, Milwaukee, Wisconsin., Cheema OM; Aurora Cardiovascular Services, Aurora Health Care, Milwaukee, Wisconsin., Downey F; Aurora Cardiovascular Services, Aurora Health Care, Milwaukee, Wisconsin., Crouch JD; Aurora Cardiovascular Services, Aurora Health Care, Milwaukee, Wisconsin.
Jazyk: angličtina
Zdroj: Journal of cardiac surgery [J Card Surg] 2019 Jun; Vol. 34 (6), pp. 453-462. Date of Electronic Publication: 2019 May 06.
DOI: 10.1111/jocs.14062
Abstrakt: Background: This study explores novel preimplantation risk factors associated with gastrointestinal bleeding (GIB) after continuous-flow left ventricular assist device (CF-LVAD) implantation. CF-LVAD therapy implantation for patients with advanced heart failure is associated with a 20% to 40% incidence of GIB.
Methods: This study includes patients receiving CF-LVAD at a quaternary medical center from 2006 to 2014 (n = 254). The primary endpoint was GIB within 12 months after implantation; the secondary outcome was 3-year all-cause mortality. The Student t test or the χ 2 test compared continuous or categorical variables. Competing risks analysis calculated the cumulative incidence of GIB postimplantation. Cox proportional hazards model was used for univariate/multivariate models predicting GIB.
Results: Sixty-four patients had GIB, with incidence rates at 1, 3, and 12 months of 11.8%, 19.3%, and 25.2%, respectively. Endoscopy revealed no identified source of bleeding in 41%; 33% of lesions were localized in the upper gastrointestinal tract, with the bulk (39%) categorized as vascular. Patients with prior gastrointestinal abnormalities (n = 98) had a greater risk of GIB post-CF-LVAD (HR 1.85 [1.11-3.09]; P = 0.02) than those with normal gastrointestinal evaluation results (n = 45) and those without preimplantation gastrointestinal evaluation (n = 111). Baseline blood urea nitrogen, chronic obstructive pulmonary disease, and prior percutaneous coronary intervention were statistically associated with post-CF-LVAD GIB. The presence of GIB within 12 months of CF-LVAD implantation was associated with an increased risk of 3-year all-cause mortality (HR 2.57 [1.57-4.15]; P < 0.01).
Conclusions: First-year GIB is associated with increased mortality post-CF-LVAD. We advocate a closer examination of several GIB risk factors when evaluating CF-LVAD candidates.
(© 2019 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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