Oral Squamous Cell Carcinomas are Associated with Poorer Outcome with Increasing Ages.

Autor:	Lubpairee T; Department of Oral Biological and Medical Sciences, Faculty of Dentistry, The University of British Columbia (BC), Vancouver, Canada.; BC Oral Cancer Prevention Program, BC Cancer Agency, Vancouver, Canada., Poh CF; Department of Oral Biological and Medical Sciences, Faculty of Dentistry, The University of British Columbia (BC), Vancouver, Canada.; BC Oral Biopsy Service, Vancouver General Hospital, Vancouver, Canada.; BC Cancer Research Centre, Vancouver, Canada., Laronde DM; Department of Oral Biological and Medical Sciences, Faculty of Dentistry, The University of British Columbia (BC), Vancouver, Canada.; BC Oral Cancer Prevention Program, BC Cancer Agency, Vancouver, Canada.; BC Oral Biopsy Service, Vancouver General Hospital, Vancouver, Canada., Rosin MP; BC Oral Biopsy Service, Vancouver General Hospital, Vancouver, Canada.; BC Cancer Research Centre, Vancouver, Canada.; School of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, Canada., Zhang L; Department of Oral Biological and Medical Sciences, Faculty of Dentistry, The University of British Columbia (BC), Vancouver, Canada.; BC Oral Cancer Prevention Program, BC Cancer Agency, Vancouver, Canada.; BC Oral Biopsy Service, Vancouver General Hospital, Vancouver, Canada.
Jazyk:	angličtina
Zdroj:	Journal of oncology research and therapy [J Oncol Res Ther] 2017; Vol. 3 (4). Date of Electronic Publication: 2017 Sep 25.
Abstrakt:	Objectives: 1.1.Although oral cancers traditionally occur in people between the age of 50 and 70, there are increasing incidences of this disease in younger and very old people. Objectives: to compare the demographics, habits, clinicopathological features, treatment and outcome of oral cancer in three age groups of patients: Young (≤ 45), Traditional (46 to 75), and Old (> 75). Subjects: 1.2.Primary oral cancers (393 patients) in a longitudinal study were used. Results: 1.3.Significant differences were noted in ethnicity (fewer Caucasian patients in Young), tobacco habit (more non-smokers in Young), location of cancer (more at tongue for Young and more at low-risk sites for Old) and treatment (more surgery for Young). Compared to Young (univariate analysis), Traditional and Old showed a 3- and 4.5-fold increase in local recurrences respectively; 1.9- and 2.7-fold increase in regional metastasis; 3.1- and 5.4-fold increase in death due to disease; and a 3.4- and 6.6-fold decrease in overall survival. Compared to Young (multivariate analysis), Traditional and Old showed a 2.4- and 3.3-fold increase in local recurrence; 2.7- and 5.4-fold increase in disease-specific survival; and 2.8- and 6.5-fold decrease in overall survival. Conclusion: 1.4.Oral cancer in different age groups showed differing ethnicity, habit, location, treatment and outcome. Competing Interests: 9. Conflict of Interest: None to declare.
Databáze:	MEDLINE
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